der Medizinischen Fakultät im Emil-Fischer-Centrum

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Lehrstuhl für Biochemie und Pathobiochemie

Leitung: Prof. Dr. Michael Wegner

2016

Baroti, T., Zimmermann, Y., Schillinger, A., Liu, L., Lommes, P., Wegner, M., Stolt, C.C. (2016)
Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.
Glia, 64, 122–138
Baroti, T., Schillinger, A., Wegner, M., Stolt, C.C. (2016)
Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
J. Neurochem., 136, 316-328
Kozlenkov, A., Wang, M., Roussos, P., Rudchenko, S., Barbu, M., Bibikova, M., Klotzle, B., Dwork, A., Zhang, B., Hurd, Y., Koonin, E., Wegner, M., Dracheva, S. (2016)
Substantial DNA Methylation Differences between Two Major Neuronal Subtypes in Human Brain.
Nucleic Acids Res., 44, 2593-2612
Küspert, M., Wegner, M. (2016)
SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors.
Brain Res., 1638, 167-182
Stolt, C.C., Wegner, M. (2016)
Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination.
Brain Res., 1641, 101-110
Moyon, S., Huynh, J.L., Dutta, D., Zhang, F., Ma, D., Yoo, S., Lawrence, R., Wegner, M., John, G.R., Emery, B., Lubetzki, C., Franklin, R.J.M., Fan, G., Zhu, J., Dupree, J.L., Casaccia, P. (2016)
Functional characterization of DNA methylation in the oligodendrocyte lineage.
Cell Reports, 15, 748–760
Ettle, B., Kerman, B.E., Valera, E., Gillmann, C., Schlachetzki, J.C., Reiprich, S., Büttner, C., Ekici, A.B., Reis, A., Wegner, M., Bäuerle, T., Riemenschneider, M.J., Masliah, E., Gage, F.H., Winkler, J. (2016)
Acta Neuropathol., 132, 59-75
Quintes, S., Brinkmann, B.G., Ebert, M., Fröb, F., Kungl, T., Arlt, F.A., Tarabykin, V., Huylebroeck, D., Meijer, D., Suter, U., Wegner, M., Sereda, M.W., Nave, K.A. (2016)
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
Nat. Neurosci., doi: 10.1038/nn.4321 (Epub ahead of print, June 13)

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2015

Lang, H., Xing, Y., Brown, L.N., Samuvel, D.J., Panganiban, C.H., Havens, L.T., Balasubramanian, S., Wegner, M., Krug, E.L., Barth, J.L. (2015)
Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve.
Sci. Rep., 5, 13383
Weider, M., Wegener, A., Schmitt, C., Küspert, M., Hillgärtner, S., Bösl, M.R., Hermans-Borgmeyer, I., Nait-Oumesmar, B., Wegner, M. (2015)
Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells
PLoS Genet., 11, e1005008
Shakhova, O., Cheng, P., Mishra, P.J. Zingg, D., Schaefer, S.M., Debbache, J., Häusel, J., Matter, C., Guo, T., Davis, S., Meltzer, P., Mihic-Probst, D., Moch, H., Wegner, M., Merlino, G., Levesque, M.P., Dummer, R., Santoro, R., Cinelli, P., Sommer, L. (2015)
Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma
PLoS Genet., 11, e1004877
Kim, G.-J., Sock, E., Buchberger, A., Just, W., Denzer, F., Hoepffner, W., German, J., Cole, T., Mann, J., Seguin, J.H., Zipf, W., Costigan, C., Rostásy, M., Kaltenbach, S., Rösler, B., Georg, I., Troppmann, E., Leipoldt, M., Widholz, S., Wieacker, P., Hiort, O., Camerino, G., Radi, O., Wegner, M., Arnold, H.-H., Scherer, G. (2015)
Copy Number Variation of Two Separate Regulatory Regions Upstream of SOX9 Cause Isolated 46,XY or 46,XX Disorder of Sex Development
J. Med. Genet., 52, 240–247
Arter, J., Wegner, M. (2015)
Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells
J. Neurochem., 132, 384-393
Anderson, S.R., Lee, I., Ebeling, C., Stephenson, D.A., Schweitzer, K.M., Baxter, D., Moon, T.M., LaPierre, S., Jaques, B., Silvius, D., Wegner, M., Hood, L.E., Carlson, G., Gunn, T.M. (2015)
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice
Mamm. Genome, 26, 80-93
Reiprich, S., Wegner, M. (2015)
From CNS stem cells to neurons and glia: Sox for everyone
Cell Tissue Res., 359, 111-124
Bischof, M., Weider, M., Küspert, M., Nave, K.-A., Wegner, M. (2015)
Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.
J. Neurosci., 35, 21-35
Quiroga, A.C., Stolt, C.C., Diez Del Corral, R., Dimitrov, S., Pérez-Alcalá, S., Sock, E., Barbas, J.A., Wegner, M., Morales, A.V. (2015)
Sox5 controls dorsal progenitor and interneuron specification in the spinal cord.
Dev. Neurobiol., in press
Wegener, A., Deboux, C., Bachelin, C., Frah, M., Kerninon, C., Seilhean, D., Weider, M., Wegner, M., Nait-Oumesmar, B. (2015)
Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination.
Brain, 138, 120-135
Amaya, D.A., Wegner, M., Stolt, C.C., Chehrehasa, F., Ekberg, J.A.K., St John, J.A. (2015)
Radial glia phagocytose axonal debris fro degenerating over-extending axons in the developing olfactory bulb.
J. Comp. Neurol., 523, 183-196

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2014

Reiprich, S., Wegner, M. (2014)
Sox2: A multitasking networker
Neurogenesis 1, e962391
Glasgow, S., Zhu, W., Stolt, C.C., Huang, T.-E., Chen, F., LoTurco, J.J., Neul, J.L., Wegner, M., Mohila, C., Deneen, B. (2014)
Mutual Antagonism Between Sox10 and NFIA Regulates Diversification of Glial Lineages and Glioma Sub-Types.
Nat. Neurosci., 17, 1322-1329
Ettle, B., Reiprich, S., Deusser, J., Schlachetzki, J.C.M., Xiang, W., Prots, I., Masliah, E., Winner, B., Wegner, M., Winkler, J. (2014)
Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells.
Mol. Cell. Neurosci., 62, 68-78
Paul, M.H., Harvey, R.P., Wegner, M., Sock, E. (2014)
Cardiac outflow
tract development relies on the complex function of Sox4 and Sox11 in multiple cell types.
Cell. Mol. Life Sci, 71, 2931-2945
May, V.E., Ettle, B., Poehler, A.M., Nuber, S., Ubhi, K., Rockenstein, E., Winner, B., Wegner, M., Masliah, E., Winkler, J. (2014)
alpha-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.
Neurobiol Aging, 35, 2357-2368
Mao, Y.Y., Reiprich, S., Wegner, M., Fritzsch, B. (2014)
Targeted deletion of Sox10 by Wnt1-cre defects: neuronal migration and projection in the mouse inner ear.
PLoS One, 9, e94580
Zhu, Q., Zhao, X., Zheng, K., Li, H., Huang, H., Zhang, Z., Mastracci, T., Wegner, M., Chen, Y., Sussel, L., Qiu, M. (2014)
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of
oligodendrocyte differentiation in the developing CNS.
Development, 141, 548-555
Hoffmann, S.A., Hos, D., Küspert, M., Lang, R.A., Lovell-Badge, R., Wegner, M., Reiprich, S. (2014)
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.
Development, 141, 39-50

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2013

Trost, A., Schrödl, F., Lange, S., Rivera, F.J., Tempfer, H., Korntner, S., Stolt, C.C., Wegner, M., Bogner, B., Kaser-Eichberger, A., Krefft, K.A., Runge, C., Aigner, L., Reitsamer, H.A. (2013)
Neural Crest Origin of Retinal and Choroidal Pericytes.
Invest Ophthalmol Vis Sci., 54, 7910-7921
Hornig J, Fröb F, Vogl MR, Hermans-Borgmeyer I, Tamm ER, Wegner M. (2013)
The transcription factors sox10 and myrf define an essential regulatory network module in differentiating oligodendrocytes.
Plos Genet, 10, e1003907
Bujalka H, Koenning M, Jackson S, Perreau VM, Pope B, Hay CM, Mitew S, Hill AF, Lu QR, Wegner M, Srinivasan R, Svaren J, Willingham M, Barres BA, Emery B. (2013)
MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes.
PLoS Biol, 11, e1001625
Harris ML, Buac K, Shakhova O, Hakami RM, Wegner M, Sommer L, Pavan WJ. (2013)
A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors
PLoS Genet, 9, e1003644
Barraud P, St John JA, Stolt CC, Wegner M, Baker (2013)
Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons.
Biol Open, 2, 750-759
Weider M, Reiprich S, Wegner M. (2013)
Sox appeal - Sox10 attracts epigenetic and transcriptional regulators in myelinating glia.
Biol Chem, 12, 1583-1593
Vogl MR, Reiprich S, Küspert M, Kosian T, Schrewe H, Nave KA, Wegner M. (2013)
Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia.
J Neurosci, 33, 6679-6690
Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO, Parkinson DB. (2013)
Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.
Brain, 136, 549-563
Wegner M. (2013)
Mighty bugs: leprosy bacteria turn schwann cells into stem cells.
Cell, 152, 15-16
Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S. (2013)
The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.
Development, 140, 740-750
Usui A, Iwagawa T, Mochizuki Y, Iida A, Wegner M, Murakami A, Watanabe S. (2013)
Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development.
FEBS Lett, 587, 358-63

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2012

Weider, M., Küspert, M., Bischof, M., Vogl, M.R., Hornig, J., Loy, K., Kosian, T., Müller, J., Hillgärtner, S., Tamm, E.R., Metzger, D., Wegner, M. (2012)
Chromatin remodelling factor Brg1 is required for Schwann cell differentiation and myelination.
Dev. Cell, 23, 193-201
Shakhova, O., Zingg, D., Schaefer, S.M., Hari, L., Civenni, G., Blunschi, J., Claudinot, S., Okoniewski, M., Beermann, F., Mihic-Probst, D., Moch, H., Wegner, M., Dummer, R., Barrandon, Y., Cinelli, P., Sommer, L. (2012)
Sox10 promotes the formation and maintenance of giant congenital nevus and melanoma.
Nat. Cell. Biol., 14, 882-890
Küspert, M., Weider, M., Müller, J., Hermans-Borgmeyer, I., Meijer, D., Wegner, M. (2012)
Desert Hedgehog links transcription factor Sox10 to perineurial development.
J. Neurosci, 32, 5472–5480
Yusuf, D., Butland, S.L., Swanson, M.I., Bolotin, E., Ticoll, A., Cheung, W.A., Zhang, X.Y., Dickman, C.T., Fulton, D.L., Lim, J.S., Schnabl, J.M., Ramos, O.H., Vasseur-Cognet, M., de Leeuw, C.N., Simpson, E.M., Ryffel, G.U., Lam, E.W., Kist, R., Wilson, M.S., Marco-Ferreres, R., Brosens, J.J., Beccari, L.L., Bovolenta, P., Benayoun, B.A., Monteiro, L.J., Schwenen, H.D., Grontved, L., Wederell, E., Mandrup, S., Veitia, R.A., Chakravarthy, H., Hoodless, P.A., Mancarelli, M., Torbett, B.E., Banham, A.H., Reddy, S.P., Cullum, R.L., Liedtke, M., Tschan, M.P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P.J., Eijkelenboom, A., Brown, P.J., Laperriere, D., Leprince, D., de Cristofaro, T., Prince, K.L., Putker, M., Del Peso, L., Camenisch, G., Wenger, R.H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S.J., Van Rechem, C., Boulay, G., Olechnowicz, S.W., Breslin, M.B., Lan, M.S., Nanan, K.K., Wegner, M., Hou, J., Mullen, R.D., Colvin, S.C., Noy, P.J., Webb, C.F., Witek, M.E., Ferrell, S., Daniel, J.M., Park, J., Waldman, S.A., Peet, D.J., Taggart, M., Jayaraman, P.S., Karrich, J.J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R.M., Woodcroft, M.W., Hough, M.R., Chen, E., Europe-Finner, N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., Lebrun, D.P., Biswal, S., Harvey, C.J., Debruyne, J.P., Hogenesch, J.B., Hevner, R.F., Heligon C., Luo, X. M., Blank, M. C., Millen, K. J., Sharlin, D. S., Forrest, D., Dahlman-Wright, K., Zhao, C. Mishima, Y. Sinha, S., Chakrabarti, R., Portales-Casamar, E., Sladek, F. M., Bradley, P. H., Wasserman, W. W. (2012)
The Transcription Factor Encyclopedia.
Genome Biology, 13:R24
Mu, L., Berti, L., Masserdotti, G., Covic, M., Michaelidis, T., Doberauer, K., Merz, K., Rehfeld, F., Haslinger, A., Wegner, M., Sock, E., Lefebvre, V., Couillard-Despres, S., Aigner, L., Berninger, B., Lie, D.C. (2012)
SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.
J. Neurosci, 32, 3067-3080
Fröb, F., Bremer, M., Finzsch, M., Kichko, T., Reeh, P., Tamm, E.R., Charnay, P., Wegner, M. (2012)
Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10.
Glia, 60, 806-819
Wahlbuhl M, Reiprich S, Vogl MR, Bösl MR, Wegner M. (2012)
Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene.
Nucleic Acids Res., 40:88-101

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2011

Wegner M. (2011)
SOX after SOX: SOXession regulates neurogenesis.
Genes Dev., 25:2423-2428
John, N., Cinelli, P., Wegner, M., Sommer, L. (2011)
Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells.
Stem Cells, 29:689-699
Bremer, M., Fröb, F., Kichko, T., Reeh, P., Tamm, E.R., Suter, U., Wegner, M. (2011)
Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve.
Glia, 59:1022-1032
Küspert, M., Hammer, A., Bösl, M.R., Wegner, M. (2011)
Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer.
Nucleic Acids Res., 39:1280-1293
Lin, L., Lee, V.M., Wang, Y., Lin, J.S., Sock, E., Wegner, M., Lei, L. (2011)
Sox11 regulates survival and axonal growth of embryonic sensory neurons.
Dev. Dyn., 240:52-64
Gallenberger, M., Meinel, D., Kroeber, M., Wegner, M., Milkereit, P., Bösl, M.R., Tamm, E.R. (2011)
Lack of Wdr36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro.
Hum. Mol. Genet., 20:422-435
Reginensi, A., Clarkson, M., Neirijnck, Y., Lu, B., Ohyama, T., Groves, A.K., Sock, E., Wegner, M., Costantini, F., Chaboissier, M.C., Schedl, A. (2011)
SOX9 controls epithelial branching by activating RET effector genes during kidney development.
Hum. Mol. Genet., 20:1143-1153

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2010

Wallace, A., Schmidt, C., Schachner, M., Wegner, M., Anderson, R. (2010)
L1cam acts as a modifier gene during enteric nervous system development.
Neurobiol. Dis., , 40, 622-633
Thein, D.C., Thalhammer, J.M., Hartwig, A.C., Crenshaw III, E.B., Lefebvre, V., Wegner, M., Sock, E. (2010)
The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development.
J. Neurochem., , 115, 131-141
Breuskin, I., Bodson, M., Thelen, N., Thiry, M., Borgs, L., Nguyen, L., Stolt, C., Wegner, M., Lefebvre, P.P., Malgrange, B. (2010)
Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10.
J. Neurochem., , 114, 1827-1839
Finzsch, M., Schreiner, S., Kichko, T., Reeh, R., Tamm, E.R., Bösl, M.R., Meijer, D., Wegner, M. (2010)
Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage.
J. Cell. Biol. , 189, 701-712
Cossais, F., Wahlbuhl, M., Kriesch, J.,Wegner, M. (2010)
SOX10 structure function analysis in the chicken reveals important insights into its role in human neurocristopathies.
Hum. Mol. Genet. , 19, 2409-2420
Bhattaram, P., Penzo-Méndez, A., Sock, E., Colmenares, C., Kaneko, K.J., Vassilev, A., DePamphilis, M.L., Wegner, M., Lefebvre, V. (2010)
Organogenesis relies on Sox4, Sox11, and Sox12 for survival of neural and mesenchymal progenitor cells.
Nat. Commun. , 1, 9
Staffler, A., Hammel, M., Wahlbuhl, M., Bidlingmaier, C., Flemmer, A.W., Pagel, P., Nicolai, T., Wegner, M., Holzinger, A. (2010)
Heterozygous SOX9 mutations allowing for residual DNA-binding and transcriptional activation lead to the acampomelic variant of Campomelic Dysplasia.
Hum. Mut. , 31, E1436-1444
Cossais, F., Sock, E., Hornig, J., Schreiner, S., Kellerer, S., Bösl, M.R., Russell, S., Wegner, M. (2010)
Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.
Dev. Biol. , 341, 267-281
Kanaykina, N., Abelson, K., King, D., Liakhovitskaia, A., Schreiner, S., Wegner, M., Kozlova, E.N. (2010)
In vitro and in vivo effects on neural crest stem cell differentiation by conditional activation of Runx1 short isoform and its effect on neuropathic pain behaviour.
Ups. J. Med. Sci. , 115, 56-64
Potzner, M.R., Tsarovina, K., Binder, E., Penzo-Méndez, A., Lefebvre, V., Rohrer, H., Wegner, M., Sock, E. (2010)
Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system.
Development , 137, 775-784
Park, J., Zhang, J.J.R., Moro, A., Kushida, M., Wegner, M., Kim, P.C.W. (2010)
Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage.
Dev. Dyn. , 239, 514-526
Guth, S.I.E., Bösl, M.R., Sock, E., Wegner, M. (2010)
Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene.
Int. J. Biochem. Cell Biol. , 42, 465-471
Stolt, C.C., Wegner, M. (2010)
SoxE function in vertebrate nervous system development.
Int. J. Biochem. Cell Biol. , 42, 437-440
Wegner, M. (2010)
All purpose SOX: The many roles of Sox proteins in gene expression.
Int. J. Biochem. Cell Biol. , 42, 381-390
Reiprich, S., Kriesch, J, Schreiner, S. Wegner, M. (2010)
Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells.
J. Neurochem. , 112, 744-754

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2009

Batista-Brito, R., Rossignol, E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis,V., Fishell, G. (2009)
The cell-intrinsic requirement of Sox6 for cortical interneuron development.
Neuron , 63, 466-481
Wolf, M., Lommes, P., Sock, E., Reiprich, S., Friedrich, R.P., Kriesch, J., Stolt, C.C., Bermingham, J.R., Wegner, M. (2009)
Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.
Dev. Biol. , 332, 418-428
Aldskogius, H., Berens, C., Kanaykina, N., Liakhovitskaia, A., Medvinsky, A., Sandelin, M., Schreiner, S., Wegner, M., Hjerling-Leffler, J., Kozlova, E.N. (2009)
Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation.
Stem Cells , 27, 1592-1603
Guth, S.I.E., Schmidt, K., Hess, A., Wegner M. (2009)
Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor.
J. Lipid Res. , 50, 1269-1280
Barrionuevo, F., Georg, I., Scherthan, H., Lécureuil, C., Guillou, F., Wegner, M., Scherer, G. (2009)
Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8.
Dev. Biol. , 327, 301-312

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2008

Reiprich, S., Stolt, C.C., Schreiner, S., Parlato, R., Wegner, M. (2008)
SoxE proteins are differentially required in mouse adrenal gland development.
Mol. Biol. Cell., 19,1575-1586
Stolt, C.C., Lommes, P., Hillgärtner, S., Wegner, M. (2008)
The transcription factor Sox5 modulates Sox10 function during melanocyte development.
Nucleic Acids Res. , 36, 5427-5440
Hoser, M., Potzner, M.R., Koch, J.M.C., Bösl, M.R., Wegner, M., Sock, E. (2008)
Sox12 deletion in the mouse reveals non-reciprocal redundancy with the related Sox4 and Sox11 transcription factors.
Mol. Cell. Biol. , 28, 4675-4687
Guth, S.I.E., Wegner, M. (2008)
Having it both ways: Sox protein function between conservation and innovation.
Cell. Mol. Life Sci. , 65, 3000-3018
Hoff, S., Zeller, F., Hann von Weyhern, C.W., Wegner, M., Schemann, M., Michel, K., Rühl, A. (2008)
Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.
J. Comp. Neurol. , 509, 356-371
Wurm, A., Sock, E., Fuchshofer, R., Wegner, M., Tamm, E.R. (2008)
Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11.
Exp. Eye Res. , 86, 895-907
Aquino, J.B., Marmigere, F., Lallemend, F., Lundgren, T.K., Villar, M.J., Wegner, M., Ernfors, P. (2008)
Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues.
Gene Expr. Patterns, 8, 217-226
Müller, S.M., Stolt, C.C., Terszowski, G., Blum, C., Amagai, T., Kessaris, N., Iannarelli, P., Richardson, W.D., Wegner, M., Rodewald, H.R. (2008)
Neural crest origin of perivascular mesenchyme in the adult thymus.
J. Immunol. , 180, 5344-5351
Wang, H., Leav, I., Ibaragi, S., Wegner, M., Hu, G.F., Lu, M., Balk, S., Yuan, X. (2008)
SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion.
Cancer Res., 68, 1625-1630
Wegner, M. (2008)
A matter of identity: transcriptional control in oligodendro-cytes.
J. Mol. Neurosci., 35, 3-12
Finzsch, M., Stolt, C.C., Lommes, P., Wegner, M. (2008)
Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression.
Development, 135, 637-646

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2007

Inoue, K., Ohyama, T., Sakuragi, Y., Li-Hua, Y., Yamamoto, R., Yu, L.-H., Goto, Y-i., Wegner, M., Lupski, J.R. (2007)
Translation of SOX10 3' untranslated region causes a complex severe neurocristopathy by generation of a deleterious functional domain.
Hum. Mol. Genet., 16, 3037-3046
Werner, T., Hammer, A., Wahlbuhl, M., Bösl, M.R., Wegner, M. (2007)
Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis.
Nucleic Acids Res., 35, 6526-6538
Schreiner, S., Cossais, F., Fischer, K., Scholz, S., Bösl, M.R., Holtmann, B., Sendtner, M., Wegner, M. (2007)
Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.
Development, 134, 3271-3281
Schlierf, B., Friedrich, R.P., Felsberg, J., Reifenberger, G., Wegner, M. (2007)
Expression of SoxE and SoxD genes in human gliomas.
Neuropathol. Appl. Neurobiol., 33, 621-630
Potzner, M.R., Griffel, C., Lütjen-Drecoll, E., Bösl, M.R., Wegner, M., Sock, E. (2007)
Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system.
Mol. Cell. Biol., 27, 5316-5326
Hoser, M., Baader, S.L., Bösl, M.R., Ihmer, A., Wegner, M., Sock, E. (2007)
Prolonged glial expression of Sox4 in the central nervous system leads to architectural cerebellar defects and ataxia.
J. Neurosci., 27, 5495-5505
Liu, Z., Hu, X., Cai, J., Liu, B., Peng, X., Wegner, M., Qiu, M. (2007)
Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms.
Dev. Biol., 302, 683-693

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2006

Stolt, C.C., Schlierf, A., Lommes, P., Hillgärtner, S., Werner, T., Kosian, T., Sock, E., Kessaris, N., Richardson, W.D., Lefebvre, V., Wegner, M. (2006)
SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.
Dev. Cell, 11, 697-709
Schlierf, B., Werner, T., Glaser, G., Wegner, M. (2006)
Expression of Connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor.
J. Mol. Biol., 361, 11-21
Kellerer, S., Schreiner, S., Stolt, C.C., Scholz, S., Bösl, M.R., Wegner, M. (2006)
Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence.
Development, 133, 2875-2886
Ito, Y., Wiese, S., Chittka, A., Rossoll, W., Bömmel, H., Watabe, K., Wegner, M., Sendtner, M. (2006)
Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells.
Proc. Natl. Acad. Sci. USA, 103, 7871-7876
Wißmüller, S., Kosian, T., Wolf, M., Wegner, M. (2006)
The High-mobility-group domain of Sox proteins interacts with the DNA-binding domains of many transcription factors.
Nucleic Acids Res., 34, 1735-1744
Marmigère, F., Montelius, A., Wegner, M., Groner, Y., Reichardt, L.F., Ernfors, P. (2006)
The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons.
Nat. Neurosci., 9, 180-187
Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., Richardson, W.D. (2006)
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an early embryonic lineage.
Nat. Neurosci., 9, 173-179
Bannykh, S.I., Stolt, C.C., Kim, J., Perry, A. and Wegner, M. (2006)
Oligo-dendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas.
J. Neurooncol., 76, 115-127

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2005

Baranek, C., Sock, E. and Wegner, M. (2005)
The POU protein Oct-6 is a nucleocytoplasmic shuttling protein.
Nucleic Acids Res., 33, 6277-6286
Schlierf, B., Lang, S., Kosian, T. and Wegner, M. (2005)
The high-mobility group transcription factor Sox10 interacts with the N-myc interacting protein Nmi.
J. Mol. Biol., 353, 1033-1042
Thomee, C., Schubert, S.W., Parma, J., Le, P.Q., Hashemolhosseini, S., Wegner, M. and Abramowicz, M.J. (2005)
GCMB mutation in familial isolated hypo-parathyroidism with residual secretion of parathyroid hormone.
J. Clin. Endocrinol. Metab., 90, 2487-2492
Stolt, C.C., Schmitt, S., Lommes, P., Sock, E. and Wegner, M. (2005)
Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.
Dev. Biol., 281, 309-317
Schmidt, K., Schinke, T., Haberland, M., Priemel, M., Schilling, A.F., Mueldner, C., Rueger, J.M., Sock, E., Wegner, M., and Amling, M. (2005)
The high-mobility-group transcription factor Sox8 is a negative regulator of osteoblast differentiation.
J. Cell. Biol., 168, 899-910
Friedrich, R., Schlierf, B., Tamm, E.R., Bösl M.R. and Wegner, M. (2005)
The class III POU domain protein Brn-1 can fully replace the related Oct-6 during Schwann cell development and myelination.
Mol. Cell. Biol., 25, 1821-1829
Maka, M., Stolt, C.C. and Wegner, M. (2005)
Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect.
Dev. Biol., 277, 155-169
Wegner, M. and Stolt, C.C. (2005)
From stem cells to neurons and glia: a soxist's view of neural development.
Trends Neurosci., 28, 583-588
Wegner, M. (2005)
Secrets to a healthy Sox life: Lessons for melanocytes.
Pigment Cell Res., 18, 74-85

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2004

Schubert, S.W., Kardash, E., Khan, M.A., Cheusova, T., Kilian, K., Wegner, M. and Hashemolhosseini, S. (2004)
Interaction, Cooperative Promoter Modulation and Renal Colocalisation of GCMa and Pitx2.
J. Biol. Chem., 279, 50358-50365
Ludwig, A., Schlierf, B., Schardt, A., Nave, K.A. and Wegner, M. (2004)
A Sox10 rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes.
Genesis, 40, 171-175
Sock, E., Rettig, S.D., Enderich, J., Bösl, M.R., Tamm, E.R. and Wegner, M. (2004)
Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling.
Mol. Cell. Biol., 24, 6635-6644
Inoue, K., Khajavi, M., Ohyama, T., Hirabayashi, S.-i., Wilson, J., Reggin, J.D., Mancias, P., Butler, I.J., Wilkinson, M.F., Wegner, M. and Lupski, J.R. (2004)
Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations.
Nature Genetics, 36, 361-369
Stolt, C.C., Lommes, P., Friedrich, R.P. and Wegner, M. (2004)
Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy.
Development, 131, 2349-2358
Chaboissier, M.-C., Kobayashi, A., Vidal, V.I.P., Lützkendorf, S., van de Kant, H.J.G., Wegner, M., de Rooij, D.G., Behringer, R.R., and Schedl, A. (2004)
Functional analysis of Sox8 and Sox9 during sex determination in the mouse.
Development, 131, 1891-1901
Hashemolhosseini, S., Schmidt, K., Kilian, K., Rodriguez, E. and Wegner, M. (2004)
Conservation and variation of structure and function in a newly identified GCM homolog from chicken
J. Mol. Biol., 336, 441-451
Ludwig, A., Rehberg, S., and Wegner, M. (2004)
Melanocyte-Specific Expression Of Dopachrome Tautomerase Is Dependent On Synergistic Gene Activation By The Sox10 And Mitf Transcription Factors.
FEBS Lett., 556, 236-244
Hashemolhosseini, S. and Wegner, M. (2004)
Impacts of a new transcription factor familiy: Mamalian GCM proteins in health and disease.
J. Cell. Biol., 166, 765-768

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2003

Hashemolhosseini, S., Kilian, K., Kardash, E., Lischka, P., Stamminger, T. and Wegner, M. (2003)
Structural requirements for nuclear localization of GCMa/Gcm-1.
FEBS Lett., 553, 315-320
Huber, W.E., Price, R., Widlund, H.R., Du, J., Davis, I.J., Wegner, M. and Fisher, D.E. (2003)
A tissue restricted cAMP transcriptional response: SOX10 modulates MSH-triggered expression of MITF in melanocytes.
J Biol. Chem., 278, 45224-45230
Schmidt, K., Glaser, G., Wernig, A., Wegner, M. and Rosorius, O. (2003)
Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis.
J. Biol. Chem., 278, 29769-29775
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Lioubinski, O., Müller, M., Wegner, M. and Sander, M. (2003)
Expression of Sox transcription factors in the developing mouse pancreas.
Dev. Dyn., 227, 402-408
Stolt, C.C., Lommes, P., Sock, E., Chaboissier, M.-C., Schedl, A. and Wegner, M. (2003)
The Sox9 transcription factor determines glial fate choice in the developing spinal cord.
Genes Dev., 17,1677-1689
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Sock, E., Pagon, R.A., Keymolen, K., Lissens, W., Wegner, M. and Scherer, G. (2003)
Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia.
Hum. Mol. Genet., 12, 1439-1447
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Cohen, S.X., Moulin, M., Hashemolhosseini, S., Kilian, K., Wegner, M. und Müller, C.W. (2003)
Structure of the GCM domain-DNA complex, a DNA-binding domain with a novel fold and mode of target site ecognition.
EMBO, 22, No. 8 pp. 1835-1845
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2002

Schlierf, B., Ludwig, A., Klenovsek, K. and Wegner, M. (2002)
Cooperative binding of Sox10 to DNA, requirements and consequences.
Nucleic Acids Res., 30, 5509-5516.
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Cohen, S.X., Moulin, M., Schilling, O. , Meyer-Klaucke, W., Schreiber, J., Wegner, M. and Müller, C.W. (2002)
The GCM-domain is a Zn-coordinating DNA-binding domain
FEBS Lett., 528, 95-100
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Hashemolhosseini, S., Hadjihannas, M., Stolt, C.C., Haas, C.S., Amann, K. and Wegner, M. (2002)
Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.
Mech. Dev., 118, 175-178
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Rehberg, S., Lischka, P., Glaser, G., Stamminger, S., Wegner, M. and Rosorius, O. (2002)
Sox10 is an active nucleocytoplasmic shuttle protein and shuttling is crucial for Sox10-mediated transactivation.
Mol. Cell. Biol., 22, 5826-5834
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Stolt, C.C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U. and Wegner, M. (2002)
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.
Genes Dev., 16, 165-170
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2001

Wegner, M. und Riethmacher, D. (2001)
Chronicles of a switch hunt, gcm genes in development.
Trends Genet., 17, 286-290
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Wegner, M. (2001)
Expression of transcription factors during oligodendroglial development.
Micros. Res. Tech., 52, 746-752
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Sonnenberg-Riethmacher, E., Miehe, M., Stolt, C.C., Goerich, D.E., Wegner M. and Riethmacher, D. (2001)
Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10.
Mech. Dev., 109, 253-265
Paratore, C., Goerich, D.E., Suter, U., Wegner, M. and Sommer, L. (2001)
Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox 10 and extrinsic combinatorial signaling.
Development, 128, 3949-3961
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Sock, E., Schmidt, K., Hermanns-Borgmeyer, I., Bösl, M.R. and Wegner, M. (2001)
Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8.
Mol. Cell. Biol., 21, 6951-6959
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Britsch, S., Goerich, D.E., Riethmacher, D., Peirano, R.I., Rossner, M., Nave, K.-A., Birchmeier, C. and Wegner M. (2001)
The transcription factor Sox10is a key regulator of peripheral glial development.
Genes Dev., 15, 66-78
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2000

Wegner, M. (2000)
Transcriptional control in glia, flavors and spices.
Glia, 31, 1-14
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Wegner, M. (2000)
Transcriptional control in glia, the basic recipe.
Glia, 29, 118-123
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Bondurand, N., Pingault, V., Goerich, D.E., Lemort, N., Sock, E., Le Caignec, C., Wegner, M. and Goossens, M. (2000)
Interaction between SOX10, PAX3 and MITF, three genes implicated in Waardenburg syndrome.
Hum. Mol. Genet., 9, 1907-1917
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Peirano, R.I. and Wegner, M. (2000)
The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences.
Nucleic Acids Res., 28, 3047-3055
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Peirano, R.I., Goerich, D.E., Riethmacher, D. and Wegner, M. (2000)
Protein zero expression is regulated by the glial transcription factor Sox10.
Mol. Cell. Biol., 20, 3198-3209
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1999

Wegner, M. (1999)
From head to toes, the multiple facets of Sox proteins.
Nucleic Acids Res., 27, 1409-1420
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Schneider, C., Wicht, H., Enderich, J., Wegner, M. and Rohrer, H. (1999)
Bone morphogenetic proteins are required for the development of sympathetic neurons.
Neuron, 24, 861-870
Bondurand, N., Kuhlbrodt, K., Pingault, V., Enderich, J., Sajus, M., Tommerup, N., Warburg, M., Hennekam, R.C.M., Read, A.P., Wegner, M. und Goossens, M. (1999)
A molecular analysis of the Yemenite deaf-blind hypopigmentation syndrome, SOX10 dysfunction causes different neurocristopathies.
Hum. Mol. Genet., 8, 1785-1789

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1998

Pingault, V., Bondurand, N., Kuhlbrodt, K., Goerich, D.E., Prèhu, M.O., Puliti, A., Herbarth, B., Hermans-Borgmeyer, I., Legius, E., Matthijs, G., Amiel, J., Lyonnet, S., Ceccherini, I., Romeo, G., Smith, J.C., Read, A.P., Wegner, M. and Goossens, M. (1998)
SOX10 mutations in patients with Waardenburg-Hirschsprung disease.
Nature Genetics, 18, 171-173
Bondurand, N., Kobetz, A., Pingault, V., Lemort, N., Encha-Razavi, F., Couly, G., Goerich, D., Wegner, M., Abitbol, M. und Goossens M. (1998)
Expression of the SOX10 gene during human development.
FEBS Lett., 432, 168-172
Kuhlbrodt, K., Schmidt, C., Sock, E., Pingault, V., Bondurand, N., Goossens, M. and Wegner, M. (1998)
Functional analysis of Sox10 mutations in human Waardenburg-Hirchsprung patients.
J. Biol. Chem., 273, 23033-23038
Kuhlbrodt, K., Herbarth, B., Sock, E., Enderich, J., Hermans-Borgmeyer, I. and Wegner, M. (1998)
Cooperativity between POU proteins and Sox proteins in glial cells.
J. Biol. Chem., 273, 16050-16057
Herbarth, B. Pingault, V., Bondurand, N., Kuhlbrodt, K., Hermans-Borgmeyer, I., Puliti, A., Lemort, N., Goossens, M. and Wegner, M. (1998)
Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease.
Proc. Natl. Acad. Sci. USA., 95, 5161-5165
Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I. and Wegner, M. (1998)
Sox10, a novel transcriptional modulator in glial cells.
J. Neurosci., 18, 237-250

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