der Medizinischen Fakultät im Emil-Fischer-Centrum

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Professur für Biochemie und Medizinische Molekularbiologie

Leitung: Prof. Dr. Ralf Enz

~Reviews

Enz R (2012)
Structure of metabotropic glutamate receptor C-terminal domains in contact with interacting proteins.
Front Mol Neurosci, 5, 52
http://www.ncbi.nlm.nih.gov/pubmed/22536173
Enz R (2012)
Metabotropic glutamate receptors and interacting proteins: Evolving drug targets
Current Drug Targets, 13, 145-156.
http://www.ncbi.nlm.nih.gov/pubmed/21777188
Enz, R (2007)
The trick of the tail: protein-protein interactions of metabotropic glutamate receptors.
BioEssays, 29, 60-73
http://www.ncbi.nlm.nih.gov/pubmed/17187376
Enz R (2001)
GABAC Receptors, A Molecular View.
Biol Chem, 382, 1111-1122
http://www.ncbi.nlm.nih.gov/pubmed/11592392
Enz R, Cutting GR (1998)
Molecular composition of GABAC receptors.
Vision Res, 38, 1431-1441
http://www.ncbi.nlm.nih.gov/pubmed/9667009

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~Buchkapitel

Seebahn A, Sticht H, Enz R (2013)
Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors.
In: G Protein Coupled Receptors: Structure, ed. P. Michael Conn
Elsevier, Methods Enzymology, Vol. 520, Chapter 12:257-279
http://www.ncbi.nlm.nih.gov/pubmed/23332704
Enz R (2008)
Binding partners of metabotropic glutamate receptors.
In: Molecular aspects of G protein-coupled receptors: Interacting proteins and function, eds. F. Ciruela and R. Lujan
Nova Science Publishers, Chapter IX, 263-292
https://www.novapublishers.com/catalog/product_info.php?products_id=5971

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Other

Derlig K, Giessl A, Brandstaetter JH, Enz R, Dahlhaus R (2015)
Special characteristics of the transcription and splicing machinery in photoreceptor cells of the mammalian retina.
Cell Tissue Res, 362:281-294
http://www.ncbi.nlm.nih.gov/pubmed/26013685
Lancrajan I, Schneider-Stock R, Naschberger E, Schellerer VS, Stuerzl M, Enz R (2015)
Absolute quantification of DcR3 and GDF15 from human serum by LC-ESI MS.
J Cell Mol Med, 19, 1656-1671
http://www.ncbi.nlm.nih.gov/pubmed/25823874
Derlig K, Ehrhardt T, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2014)
Simiate is an Actin binding protein involved in filopodia dynamics and arborization of neurons.
Front Cell Neurosci, 8, article 99
http://www.ncbi.nlm.nih.gov/pubmed/24782708
Derlig K, Gießl A,Brandstätter JH, Enz R, Dahlhaus R (2013)
Identification and Characterisation of Simiate, a Novel Protein Linked to the Fragile X Syndrome.
PLoS One, 8, e83007
http://www.ncbi.nlm.nih.gov/pubmed/24349419
Fuchs M, Scholz M, Sendelbeck A, Atorf J, Schlegel C, Enz R, Brandstätter JH (2012)
Rod photoreceptor ribbon synapses in DBA/2J mice show progressive age-related structural changes.
PLoS One, 7, e44645
http://www.ncbi.nlm.nih.gov/pubmed/22957094

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Glycine Receptors

Heck S, Enz R, Richter-Landsberg C, Blohm D (1997)
Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.
Dev Brain Res, 98, 211-220
http://www.ncbi.nlm.nih.gov/pubmed/9051263
Enz R, Bormann J (1995)
Expression of glycine receptor subunits and gephyrin in single bipolar cells of the rat retina.
Visual Neurosci, 12, 501-507
http://www.ncbi.nlm.nih.gov/pubmed/7544608

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Glutamate Receptors

Duetting E, Schroeder-Kress N, Sticht H, Enz R (2011)
Sumo E3 ligases are expressed in the retina and regulate sumoylation of the metabotropic glutamate receptor 8b.
Biochem J, 435, 365-371
http://www.ncbi.nlm.nih.gov/pubmed/21288202
Seebahn A, Dinkel H, Mohrlüder J, Hartmann R, Vogel N, Becker CM, Sticht H, Enz R (2011)
Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors.
FEBS Letters, 585, 511-516
http://www.ncbi.nlm.nih.gov/pubmed/21219903
Rose M, Dütting E, Enz R (2008)
Band 4.1 proteins are expressed in the retina and interact with both isoforms of the metabotropic glutamate receptor type 8.
J Neurochem, 105, 2375-2387
http://www.ncbi.nlm.nih.gov/pubmed/18373558
Seebahn A, Rose M, Enz R. (2008)
RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors.
FEBS Letters, 582, 24532457
http://www.ncbi.nlm.nih.gov/pubmed/18555800
Meiselbach H, Sticht H, Enz R (2006)
Structural Analysis of the Protein Phosphatase 1 Docking Motif: Molecular Description of Binding Specificities Identifies Interacting Proteins.
Chemistry & Biology, 13, 49-59
http://www.ncbi.nlm.nih.gov/pubmed/16426971
Dyka FM, May CA, Enz R (2004)
Metabotropic glutamate are differentially regulated under elevated intraocular pressure.
J Neurochem, 90, 190-202
http://www.ncbi.nlm.nih.gov/pubmed/15198678
Enz R, Croci C (2003)
Different binding domains in the metabotropic glutamate receptor type 7b for Filamin-A, PP1C, PICK1 and Syntenin allow the formation of multimeric protein complexes.
Biochem J, 372, 183-191
http://www.ncbi.nlm.nih.gov/pubmed/12570872
Croci C, Sticht H, Brandstaetter JH, Enz R (2003)
Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences.
J Biol Chem, 278, 50682-50690
http://www.ncbi.nlm.nih.gov/pubmed/14519764
Enz R (2002)
The metabotropic glutamate receptor mGluR7b binds to the catalytic γ-subunit of protein phosphatase 1.
J Neurochem, 81, 1-11
http://www.ncbi.nlm.nih.gov/pubmed/12065625
Enz R (2002)
The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.
FEBS letters, 514, 184-188
http://www.ncbi.nlm.nih.gov/pubmed/11943148
Heck S, Enz R, Richter-Landsberg C, Blohm D (1997)
Expression of eight metabotropic glutamate receptor subtypes during neuronal differentiation of P19 embryocarcinoma cells, a study by RT-PCR and in situ hybridization.
Dev Brain Res, 101, 85-91
http://www.ncbi.nlm.nih.gov/pubmed/9263583
Hartveit E, Brandstätter H, Enz R, Wässle H (1995)
Expression of the mRNA of seven metabotropic glutamate receptors (mGluR1 to 7) in the rat retina. An in situ hybridization study on tissue sections and isolated cells.
Eur J Neurosci, 7, 1472-1483
http://www.ncbi.nlm.nih.gov/pubmed/7551173

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GABA Receptors

Linck L, Binder J, Haynl C, Enz R (2015)
Endocytosis of GABAc receptors depends on subunit composition and is regulated by protein kinase C-ζ and protein phosphatase 1.
J Neurochem, 134, 233-246
http://www.ncbi.nlm.nih.gov/pubmed/25868914
Urbanczyk A, Jünemann A, Enz R (2011)
PKCζ-interacting protein ZIP3 is generated by intronic polyadenylation, and is expressed in the brain and retina of the rat.
Biochem J, 433, 43-50
http://www.ncbi.nlm.nih.gov/pubmed/20979579
Urbanczyk A, Enz R (2011)
Spartin recruits PKC-ζ via the PKC-ζ interacting proteins ZIP1 and ZIP3 to lipid droplets.
J Neurochem, 118, 737-748
http://www.ncbi.nlm.nih.gov/pubmed/21707618
Rose M, Dütting E, Schröder N, Sticht H, Brandstätter JH, Enz R. (2008)
PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.
Mol Cell Neurosci, 37, 808-819
http://www.ncbi.nlm.nih.gov/pubmed/18325784
Ulrich M, Seeber S, Becker CM, Enz R (2007)
Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit.
Biochem J, 401, 429-436
http://www.ncbi.nlm.nih.gov/pubmed/16999686
Alakuijala A, Palgi M, Wegelius K, Schmidt M, Enz R, Paulin L, Saarma M, Pasternack M (2005)
GABA receptor ρ subunit expression in the developing rat brain.
Brain Res Dev Brain Res, 154, 15-23
http://www.ncbi.nlm.nih.gov/pubmed/15617751
Croci C, Brandstätter JH, Enz R (2003)
ZIP3, a New Splice Variant of the PKC-ζ interacting Protein Family, Binds to GABAC Receptors, PKC-ζ and Kvβ2.
J Biol Chem, 278, 6128-6135
http://www.ncbi.nlm.nih.gov/pubmed/12431995
Enz R, Cutting, GR (1999)
Identification of 70 amino acids important for GABAC receptor ρ subunit assembly.
Brain Res, 846, 177-185
http://www.ncbi.nlm.nih.gov/pubmed/10556634
Enz R, Cutting GR (1999)
GABAC receptor ρ subunits are heterogeneously expressed in the human CNS and form homo- and heterooligomers with distinct physical properties.
Eur J Neurosci, 11, 41-50
http://www.ncbi.nlm.nih.gov/pubmed/9987010
Koulen P, Brandstätter H, Enz R, Bormann J, Wässle H (1998)
Synaptic clustering of GABAC receptor ρ subunits in the rat retina.
Eur J Neurosci, 10, 115-127
http://www.ncbi.nlm.nih.gov/pubmed/9753119
Koulen P, Brandstätter H, Kröger S, Enz R, Bormann J, Wässle H (1997)
Immunocytochemical localization of the GABAC receptor ρ subunits in the cat, goldfish and chicken retina.
J Comp Neurol, 380, 520-542
http://www.ncbi.nlm.nih.gov/pubmed/9087530
Enz R, Brandstätter H, Wässle H, Bormann J (1996)
Immunocytochemical localization of GABAC receptor ρ subunits in the mammalian retina.
J Neurosci, 16, 4479-4490
http://www.ncbi.nlm.nih.gov/pubmed/8699258
Enz R, Bormann J (1995)
A single point mutation decreases picrotoxinin sensitivity of the human GABA receptor ρ1 subunit.
Neuroreport, 6, 45-48
http://www.ncbi.nlm.nih.gov/pubmed/7579151
Enz R, Brandstätter H, Hartveit E, Wässle H, Bormann J (1995)
Expression of GABA receptor subunits ρ1 and ρ2 in the retina and brain of the rat.
Eur J Neurosci, 7,1495-1501
http://www.ncbi.nlm.nih.gov/pubmed/7551175

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Epithelial Sodium Channels

Dyka FM, May CA, Enz R (2005)
Subunits of the epithelial sodium channel family are differentially expressed in the retina of mice with ocular hypertension.
J Neurochem, 94, 120-128
http://www.ncbi.nlm.nih.gov/pubmed/15953355

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Chloride Channels

Hohberger B, Enz R (2009)
Cereblon is expressed in the retina and binds to voltage-gated chloride channels.
FEBS Letters, 583, 633-637
http://www.ncbi.nlm.nih.gov/pubmed/19166841
Enz R, Ross BJ, Cutting GR (1999)
Expression of the voltage-gated chloride channel ClC-2 in rod bipolar cells of the rat retina.
J Neurosci, 22, 9841-9847
http://www.ncbi.nlm.nih.gov/pubmed/10559393

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Acetylcholine Receptors

Cheusova T, Khan MA, Enz R, Hashemolhosseini S (2006)
Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina.
J Neurochem, 99, 450-457
http://www.ncbi.nlm.nih.gov/pubmed/16899069

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