der Medizinischen Fakultät im Emil-Fischer-Centrum

Navigation überspringen

Professur für Biochemie und Medizinische Molekularbiologie

Leitung: Prof. Dr. Ralf Enz


Enz R (2012)
Structure of metabotropic glutamate receptor C-terminal domains in contact with interacting proteins.
Front Mol Neurosci, 5, 52
Enz R (2012)
Metabotropic glutamate receptors and interacting proteins: Evolving drug targets
Current Drug Targets, 13, 145-156.
Enz, R (2007)
The trick of the tail: protein-protein interactions of metabotropic glutamate receptors.
BioEssays, 29, 60-73
Enz R (2001)
GABAC Receptors, A Molecular View.
Biol Chem, 382, 1111-1122
Enz R, Cutting GR (1998)
Molecular composition of GABAC receptors.
Vision Res, 38, 1431-1441

nach oben


Seebahn A, Sticht H, Enz R (2013)
Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors.
In: G Protein Coupled Receptors: Structure, ed. P. Michael Conn
Elsevier, Methods Enzymology, Vol. 520, Chapter 12:257-279
Enz R (2008)
Binding partners of metabotropic glutamate receptors.
In: Molecular aspects of G protein-coupled receptors: Interacting proteins and function, eds. F. Ciruela and R. Lujan
Nova Science Publishers, Chapter IX, 263-292

nach oben


Derlig K, Giessl A, Brandstaetter JH, Enz R, Dahlhaus R (2015)
Special characteristics of the transcription and splicing machinery in photoreceptor cells of the mammalian retina.
Cell Tissue Res, 362:281-294
Lancrajan I, Schneider-Stock R, Naschberger E, Schellerer VS, Stuerzl M, Enz R (2015)
Absolute quantification of DcR3 and GDF15 from human serum by LC-ESI MS.
J Cell Mol Med, 19, 1656-1671
Derlig K, Ehrhardt T, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2014)
Simiate is an Actin binding protein involved in filopodia dynamics and arborization of neurons.
Front Cell Neurosci, 8, article 99
Derlig K, Gießl A,Brandstätter JH, Enz R, Dahlhaus R (2013)
Identification and Characterisation of Simiate, a Novel Protein Linked to the Fragile X Syndrome.
PLoS One, 8, e83007
Fuchs M, Scholz M, Sendelbeck A, Atorf J, Schlegel C, Enz R, Brandstätter JH (2012)
Rod photoreceptor ribbon synapses in DBA/2J mice show progressive age-related structural changes.
PLoS One, 7, e44645

nach oben

Glycine Receptors

Heck S, Enz R, Richter-Landsberg C, Blohm D (1997)
Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.
Dev Brain Res, 98, 211-220
Enz R, Bormann J (1995)
Expression of glycine receptor subunits and gephyrin in single bipolar cells of the rat retina.
Visual Neurosci, 12, 501-507

nach oben

Glutamate Receptors

Duetting E, Schroeder-Kress N, Sticht H, Enz R (2011)
Sumo E3 ligases are expressed in the retina and regulate sumoylation of the metabotropic glutamate receptor 8b.
Biochem J, 435, 365-371
Seebahn A, Dinkel H, Mohrlüder J, Hartmann R, Vogel N, Becker CM, Sticht H, Enz R (2011)
Structural characterization of intracellular C-terminal domains of group III metabotropic glutamate receptors.
FEBS Letters, 585, 511-516
Rose M, Dütting E, Enz R (2008)
Band 4.1 proteins are expressed in the retina and interact with both isoforms of the metabotropic glutamate receptor type 8.
J Neurochem, 105, 2375-2387
Seebahn A, Rose M, Enz R. (2008)
RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors.
FEBS Letters, 582, 24532457
Meiselbach H, Sticht H, Enz R (2006)
Structural Analysis of the Protein Phosphatase 1 Docking Motif: Molecular Description of Binding Specificities Identifies Interacting Proteins.
Chemistry & Biology, 13, 49-59
Dyka FM, May CA, Enz R (2004)
Metabotropic glutamate are differentially regulated under elevated intraocular pressure.
J Neurochem, 90, 190-202
Enz R, Croci C (2003)
Different binding domains in the metabotropic glutamate receptor type 7b for Filamin-A, PP1C, PICK1 and Syntenin allow the formation of multimeric protein complexes.
Biochem J, 372, 183-191
Croci C, Sticht H, Brandstaetter JH, Enz R (2003)
Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences.
J Biol Chem, 278, 50682-50690
Enz R (2002)
The metabotropic glutamate receptor mGluR7b binds to the catalytic γ-subunit of protein phosphatase 1.
J Neurochem, 81, 1-11
Enz R (2002)
The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.
FEBS letters, 514, 184-188
Heck S, Enz R, Richter-Landsberg C, Blohm D (1997)
Expression of eight metabotropic glutamate receptor subtypes during neuronal differentiation of P19 embryocarcinoma cells, a study by RT-PCR and in situ hybridization.
Dev Brain Res, 101, 85-91
Hartveit E, Brandstätter H, Enz R, Wässle H (1995)
Expression of the mRNA of seven metabotropic glutamate receptors (mGluR1 to 7) in the rat retina. An in situ hybridization study on tissue sections and isolated cells.
Eur J Neurosci, 7, 1472-1483

nach oben

GABA Receptors

Linck L, Binder J, Haynl C, Enz R (2015)
Endocytosis of GABAc receptors depends on subunit composition and is regulated by protein kinase C-ζ and protein phosphatase 1.
J Neurochem, 134, 233-246
Urbanczyk A, Jünemann A, Enz R (2011)
PKCζ-interacting protein ZIP3 is generated by intronic polyadenylation, and is expressed in the brain and retina of the rat.
Biochem J, 433, 43-50
Urbanczyk A, Enz R (2011)
Spartin recruits PKC-ζ via the PKC-ζ interacting proteins ZIP1 and ZIP3 to lipid droplets.
J Neurochem, 118, 737-748
Rose M, Dütting E, Schröder N, Sticht H, Brandstätter JH, Enz R. (2008)
PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.
Mol Cell Neurosci, 37, 808-819
Ulrich M, Seeber S, Becker CM, Enz R (2007)
Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit.
Biochem J, 401, 429-436
Alakuijala A, Palgi M, Wegelius K, Schmidt M, Enz R, Paulin L, Saarma M, Pasternack M (2005)
GABA receptor ρ subunit expression in the developing rat brain.
Brain Res Dev Brain Res, 154, 15-23
Croci C, Brandstätter JH, Enz R (2003)
ZIP3, a New Splice Variant of the PKC-ζ interacting Protein Family, Binds to GABAC Receptors, PKC-ζ and Kvβ2.
J Biol Chem, 278, 6128-6135
Enz R, Cutting, GR (1999)
Identification of 70 amino acids important for GABAC receptor ρ subunit assembly.
Brain Res, 846, 177-185
Enz R, Cutting GR (1999)
GABAC receptor ρ subunits are heterogeneously expressed in the human CNS and form homo- and heterooligomers with distinct physical properties.
Eur J Neurosci, 11, 41-50
Koulen P, Brandstätter H, Enz R, Bormann J, Wässle H (1998)
Synaptic clustering of GABAC receptor ρ subunits in the rat retina.
Eur J Neurosci, 10, 115-127
Koulen P, Brandstätter H, Kröger S, Enz R, Bormann J, Wässle H (1997)
Immunocytochemical localization of the GABAC receptor ρ subunits in the cat, goldfish and chicken retina.
J Comp Neurol, 380, 520-542
Enz R, Brandstätter H, Wässle H, Bormann J (1996)
Immunocytochemical localization of GABAC receptor ρ subunits in the mammalian retina.
J Neurosci, 16, 4479-4490
Enz R, Bormann J (1995)
A single point mutation decreases picrotoxinin sensitivity of the human GABA receptor ρ1 subunit.
Neuroreport, 6, 45-48
Enz R, Brandstätter H, Hartveit E, Wässle H, Bormann J (1995)
Expression of GABA receptor subunits ρ1 and ρ2 in the retina and brain of the rat.
Eur J Neurosci, 7,1495-1501

nach oben

Epithelial Sodium Channels

Dyka FM, May CA, Enz R (2005)
Subunits of the epithelial sodium channel family are differentially expressed in the retina of mice with ocular hypertension.
J Neurochem, 94, 120-128

nach oben

Chloride Channels

Hohberger B, Enz R (2009)
Cereblon is expressed in the retina and binds to voltage-gated chloride channels.
FEBS Letters, 583, 633-637
Enz R, Ross BJ, Cutting GR (1999)
Expression of the voltage-gated chloride channel ClC-2 in rod bipolar cells of the rat retina.
J Neurosci, 22, 9841-9847

nach oben

Acetylcholine Receptors

Cheusova T, Khan MA, Enz R, Hashemolhosseini S (2006)
Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina.
J Neurochem, 99, 450-457

nach oben