der Medizinischen Fakultät im Emil-Fischer-Centrum

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AG Sock

Leitung: PD Dr. Elisabeth Sock


Chen C., Lee G.A., Pourmorady A., Sock E., Donoghue M.J. (2015)
Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes
J. Neurosci., 35:10629-10642
Kim, G.-J., Sock, E., Buchberger, A., Just, W., Denzer, F., Hoepffner, W., German, J., Cole, T., Mann, J., Seguin, J.H., Zipf, W., Costigan, C., Rostásy, M., Kaltenbach, S., Rösler, B., Georg, I., Troppmann, E., Leipoldt, M., Widholz, S., Wieacker, P., Hiort, O., Camerino, G., Radi, O., Wegner, M., Arnold, H.-H., Scherer, G. (2015)
Copy Number Variation of Two Separate Regulatory Regions Upstream of SOX9 Cause Isolated 46,XY or 46,XX Disorder of Sex Development
J. Med. Genet., 52:240-247
Quiroga AC, Stolt CC, Diez Del Corral R, Dimitrov S, Pérez-Alcalá S, Sock E, Barbas JA, Wegner M, Morales AV (2014)
Sox5 controls dorsal progenitor and interneuron specification in the spinal cord.
Dev Neurobiol, 75:522-538
Pérez-Brangulí F, Mishra HK, Prots I, Havlicek S, Kohl Z, Saul D, Rummel C, Dorca-Arevalo J, Regensburger M, Graef D, Sock E, Blasi J, Groemer TW, Schlötzer-Schrehardt U, Winkler J, Winner B (2014)
Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia.
Hum Mol Genet, 23, 4859-4874
Paul MH, Harvey RP, Wegner M, Sock E (2014)
Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types.
Cell Mol Life Sci,, 71, 2931-2945
Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO, Parkinson DB (2013)
Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells
Brain, 136:549-563
Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S (2013)
The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells
Development, 140:740-750
Mu L, Berti L, Masserdotti G, Covic M, Michaelidis TM, Doberauer K, Merz K, Rehfeld F, Haslinger A, Wegner M, Sock E, Lefebvre V, Couillard-Despres S, Aigner L, Berninger B, Lie DC (2012)
SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis
J Neurosci, 32:3067-3080
Lin L, Lee VM, Wang Y, Lin JS, Sock E, Wegner M, Lei L (2011)
Sox11 regulates survival and axonal growth of embryonic sensory neurons
Dev Dyn, 240:52-64
Reginensi A, Clarkson M, Neirijnck Y, Lu B, Ohyama T, Groves AK, Sock E, Wegner M, Costantini F, Chaboissier MC, Schedl A (2011)
SOX9 Controls Epithelial Branching by Activating RET Effector Genes during Kidney Development
Hum Mol Genet, 20:1143-1153
Hörnblad A, Eriksson AU, Sock E, Hill RE, Ahlgren U (2011)
Impaired spleen formation perturbs morphogenesis of the gastric lobe of the pancreas
PLoS One, 6:e21753
Thein, D.C., Thalhammer, J.M., Hartwig, A.C., Crenshaw III, E.B., Lefebvre, V., Wegner, M., Sock, E. (2010)
The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development.
J. Neurochem., 115, 131-141
Bhattaram, P., Penzo-Méndez, A., Sock, E., Colmenares, C., Kaneko, K.J., Vassilev, A., DePamphilis, M.L., Wegner, M., Lefebvre, V. (2010)
Organogenesis relies on Sox4, Sox11, and Sox12 for survival of neural and mesenchymal progenitor cells.
Nat. Commun. , 1, 9
Cossais, F., Sock, E., Hornig, J., Schreiner, S., Kellerer, S., Bösl, M.R., Russell, S., Wegner, M. (2010)
Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.
Dev. Biol. , 341, 267-281
Potzner, M.R., Tsarovina, K., Binder, E., Penzo-Méndez, A., Lefebvre, V., Rohrer, H., Wegner, M., Sock, E. (2010)
Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system.
Development , 137, 775-784
Guth, S.I.E., Bösl, M.R., Sock, E., Wegner, M. (2010)
Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene.
Int. J. Biochem. Cell Biol. , 42, 465-471
Wolf, M., Lommes, P., Sock, E., Reiprich, S., Friedrich, R.P., Kriesch, J., Stolt, C.C., Bermingham, J.R., Wegner, M. (2009)
Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.
Dev. Biol. , 332, 418-428
Hoser, M., Potzner, M.R., Koch, J.M.C., Bösl, M.R., Wegner, M., Sock, E. (2008)
Sox12 deletion in the mouse reveals non-reciprocal redundancy with the related Sox4 and Sox11 transcription factors.
Mol. Cell. Biol. , 28, 4675-4687
Wurm, A., Sock, E., Fuchshofer, R., Wegner, M., Tamm, E.R. (2008)
Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11.
Exp. Eye Res. , 86, 895-907
Potzner, M.R., Griffel, C., Lütjen-Drecoll, E., Bösl, M.R., Wegner, M., Sock, E. (2007)
Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system.
Mol. Cell. Biol., 27, 5316-5326
Hoser, M., Baader, S.L., Bösl, M.R., Ihmer, A., Wegner, M., Sock, E. (2007)
Prolonged glial expression of Sox4 in the central nervous system leads to architectural cerebellar defects and ataxia.
J. Neurosci., 27, 5495-5505
Stolt, C.C., Schlierf, A., Lommes, P., Hillgärtner, S., Werner, T., Kosian, T., Sock, E., Kessaris, N., Richardson, W.D., Lefebvre, V., Wegner, M. (2006)
SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.
Dev. Cell, 11, 697-709
Baranek, C., Sock, E. and Wegner, M. (2005)
The POU protein Oct-6 is a nucleocytoplasmic shuttling protein.
Nucleic Acids Res., 33, 6277-6286
Stolt, C.C., Schmitt, S., Lommes, P., Sock, E. and Wegner, M. (2005)
Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.
Dev. Biol., 281, 309-317
Schmidt, K., Schinke, T., Haberland, M., Priemel, M., Schilling, A.F., Mueldner, C., Rueger, J.M., Sock, E., Wegner, M., and Amling, M. (2005)
The high-mobility-group transcription factor Sox8 is a negative regulator of osteoblast differentiation.
J. Cell. Biol., 168, 899-910
Sock, E., Rettig, S.D., Enderich, J., Bösl, M.R., Tamm, E.R. and Wegner, M. (2004)
Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling.
Mol. Cell. Biol., 24, 6635-6644
Stolt CC, Lommes P, Sock E, Chaboissier MC, Schedl A, Wegner M (2003)
The Sox9 transcription factor determines glial fate choice in the developing spinal cord
Genes Dev, 17,1677-1689
Sock, E., Pagon, R.A., Keymolen, K., Lissens, W., Wegner, M. and Scherer, G. (2003)
Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia.
Hum. Mol. Genet., 12, 1439-1447
Sock, E., Schmidt, K., Hermanns-Borgmeyer, I., Bösl, M.R. and Wegner, M. (2001)
Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8.
Mol. Cell. Biol., 21, 6951-6959
Bondurand, N., Pingault, V., Goerich, D.E., Lemort, N., Sock, E., Le Caignec, C., Wegner, M. and Goossens, M. (2000)
Interaction between SOX10, PAX3 and MITF, three genes implicated in Waardenburg syndrome.
Hum. Mol. Genet., 9, 1907-1917
Sock E, Enderich J, Wegner M (1999)
The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP
Mol Cell Biol , 19, 2455-2464
Kuhlbrodt, K., Schmidt, C., Sock, E., Pingault, V., Bondurand, N., Goossens, M. and Wegner, M. (1998)
Functional analysis of Sox10 mutations in human Waardenburg-Hirchsprung patients.
J. Biol. Chem., 273, 23033-23038
Kuhlbrodt, K., Herbarth, B., Sock, E., Enderich, J., Hermans-Borgmeyer, I. and Wegner, M. (1998)
Cooperativity between POU proteins and Sox proteins in glial cells.
J. Biol. Chem., 273, 16050-16057
Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I. and Wegner, M. (1998)
Sox10, a novel transcriptional modulator in glial cells.
J. Neurosci., 18, 237-250
Schreiber J, Enderich J, Sock E, Schmidt C, Richter-Landsberg C, Wegner M (1997)
Redundancy of class III POU proteins in the oligodendrocyte lineage
J Biol Chem, 272, 32286-32293
Nesper J, Smith RW, Kautz AR, Sock E, Wegner M, Grummt F, Nasheuer HP (1997)
A cell-free replication system for human polyomavirus JC DNA
J Virol, 71, 7421-7428
Sock E, Leger H, Kuhlbrodt K, Schreiber J, Enderich J, Richter-Landsberg C, Wegner M (1997)
Expression of Krox proteins during differentiation of the O-2A progenitor cell line CG-4
J Neurochem, 68, 1911-1919
Schreiber J, Sock E, Wegner M (1997)
The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain
Proc Natl Acad Sci U S A, 94, 4739-4744
Renner K, Sock E, Gerber JK, Wegner M (1996)
T antigen of human papovavirus JC stimulates transcription of the POU domain factor Tst-1/Oct6/SCIP
DNA Cell Biol, 15, 1057-1062
Renner K, Sock E, Bermingham JR Jr, Wegner M (1996)
Expression of the gene for the POU domain transcription factor Tst-1/Oct6 is regulated by an estrogen-dependent enhancer
Nucleic Acids Res, 24, 4552-4557
Sock E, Enderich J, Rosenfeld MG, Wegner M (1996)
Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6
J Biol Chem, 271, 17512-17518
Sock E, Renner K, Feist D, Leger H, Wegner M (1996)
Functional comparison of PML-type and archetype strains of JC virus
J Virol, 70, 1512-1520
Terlecky SR, Nuttley WM, McCollum D, Sock E, Subramani S (1995)
The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C-terminal tripeptide peroxisomal targeting signal
EMBO J, 14, 3627-3634
Leger H, Sock E, Renner K, Grummt F, Wegner M (1995)
Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y
Mol Cell Biol, 15, 3738-3747
Sock E, Wegner M, Fortunato EA, Grummt F (1993)
Large T-antigen and sequences within the regulatory region of JC virus both contribute to the features of JC virus DNA replication
Virology, 197, 537-548
Sock E, Wegner M, Grummt F (1991)
DNA replication of human polyomavirus JC is stimulated by NF-I in vivo
Virology, 182, 298-308
Lorenz U, Sock E, Grummt F, Moelling K (1991)
Analysis of DNA sequences present in complexes of v-Myc and cellular DNA
Oncogene, 6, 51-57

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