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Professur für Biochemie

Leitung: Prof. Dr. Ewald Hannappel

0. Review

Hannappel, E. (2007)
Ann N Y Acad Sci, 1112, 21-37
Hannappel, E.; Huff, T.; Safer, D. (2006)
Intracellular beta-thymosins. In "Actin-Monomer-Binding Proteins", ed. by P. Lappalainen
Hannappel, E.; Huff, T. (2003)
The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins, Structure and function
Vitamins and Hormones, 66, 257-296
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Huff, T.; Müller, C. S. G.; Otto, A. M.; Netzker, R.; Hannappel, E. (2001)
beta-Thymosins, small acidic peptides with multiple functions.
Int. J. Biochem. Cell Biology, 33, 205-220
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Huff, T.; Müller, C.; Hannappel, E. (1997)
HPLC and post-column derivatization with fluorescamine, isolation of actin- sequestering beta-thymosins by reverse-phase HPLC.
Anal. Chim. Acta, 352, 239-248
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Horecker, B. L.; Erickson-Viitanen, S.; Hannappel, E. (1985)
Thymosin beta 4-like peptides.
Meth. Enzymol., 116, 265-269,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4088088&dopt=Abstract

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I. Thymosins

J. Knop, C. App, T. Huff, F. Iavarone, M. Castagnola, E. Hannappel (2015)
Identification of PDGF-BB binding to thymosin beta-4 by chemical crosslinking
Expert Opin Biol Ther, in press
T. Cabras, F. Iavarone, C. Martelli, D. Delfino, D.V. Rossetti, I. Insera, B. Manconi, C. Desiderio, I. Messana, E. Hannappel, G. Faa, M. Castagnola (2015)
High-resolution mass spectrometry for thymosin detection and characterization
Expert Opin Biol Ther, in press
Christine App, Jana Knop, Thomas Huff, Angela Seebahn,Cord-Michael Becker, Federica Iavarone, Massimo Castagnola and Ewald Hannappel (2014)
Peptide labeling with photoactivatable trifunctional cadaverine derivative and identification of interacting partners by biotin transfer.
Anal. Biochem., 456,14-21
Al Haj, A. Mazur, A. App, C. Theiss, C. Silvan, U. Schoenenberger, C.A. Jokusch, B.M., Hannappel, E., Weeds, A.G. Mannherz, H. G. (2014)
Thymosin beta4 inhibits ADF/cofilin stimulated F-actin cycling and cell migration: reversal by active Arp2/3 complex
Cytoskeleton, 71, 95-107
Hinkel, R., Trenkwalder, T., Petersen, B., Husada, W., Gesenhues, F., Seugmin, S., Hannappel, E., Bock-Marquette, I Theisen, D., Leitner, L., Boeckstegers, P., Cierniewski, C. S., Mueller, O.J., le Noble, F., Adams, R.H., Weinl, C.; Nordheim, A., Reichart, B., Weber, C., Olson, E. N., Posern, G., Deindl, E., Niemann, H., Kupatt, C. (2013)
MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Nat Commun, im Druck
Jana Knop, Christine App, Anselm H. C. Horn, Federica Iavarone, Massimo Castagnola, and Ewald Hannappel (2013)
High-resolution HPLC-ESI-MS characterization of the contact sites of the actin-thymosin beta(4) complex by chemical and enzymatic cross-linking.
BIochemistry, 51, 5553-62
Christine App, Jana Knop, Thomas Huff, Heinrich Sticht and Ewald Hannappel (2013)
Thymosin beta-4 and Tissue Transglutaminase. Molecular Characterization of Cyclic
Thymosin beta-4
Goldstein, A. L. Hannappel, E. Sosne, G. Kleinman, H. K. (2012)
Thymosin beta-4: a multi-functional regenerative peptide. Basic properties and clinical applications
Expert Opin Biol Ther, 12, 37-51
Expert Opin Biol Ther
App, C. Knop, J. Mannherz, H. G. Hannappel, E. (2012)
Identification of interaction partners of beta-thymosins: application of thymosin beta4 labeled by transglutaminase
Ann N Y Acad Sci, 1270, 98-104
Knop, J. App, C. Hannappel, E. (2012)
Antibodies in research of thymosin beta4: investigation of cross-reactivity and influence of fixatives
Ann N Y Acad Sci, 1270, 105-111
Mannherz, H. G. Hannappel, E. (2009)
The b-thymosins: Intracellular and extracellular activities of a versatile actin binding protein family
Cell Motil Cytoskeleton, 66, 839-851
Hinkel, R.; El-Aouni, C.; Olson, T.; Horstkotte, J.; Mayer, S.; Muller, S.; Willhauck, M.; Spitzweg, C.; Gildehaus, F. J.; Munzing, W.; Hannappel, E.; Bock-Marquette, I.; DiMaio, J. M.; Hatzopoulos, A. K.; Boekstegers, P.; Kupatt, C. (2008)
Thymosin beta-4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection
Circulation, 117, 2232-40
Zoubek, R.E.; Hannappel, E. (2007)
Influence of the N terminus and the actin-binding motif of thymosin beta-4 on its interaction with G-actin
Ann N Y Acad Sci, 1112, 435-41
Zoubek, R.E.; Hannappel, E. (2007)
Subcellular distribution of thymosin beta-4
Ann N Y Acad Sci, 1112, 442-50
Huff, T.; Müller, C.S.G.; Hannappel, E. (2007)
Thymosin beta-4 is not always the main beta-thymosin in mammalian platelets
Ann N Y Acad Sci, 1112, 451-7
Bodendorf, S.; Born, G.; Hannappel, E. (2007)
Determination of thymosin beta-4 and protein in human wound fluid after abdominal surgery
Ann N Y Acad Sci, 1112, 418-24
Baraaeva, E.; Agladze, N.; Hannappel, E. Sjogren, M.H., Rojkind, M. (2007)
Thymosin beta-4 up-regulates the expression of hepatocyte growth factor and down-regulates the expression of PDGF-beta receptor in human hepatic stellate cells
Ann N Y Acad Sci, 1112, 154-60
Goldstein, A. L.; Hannappel, E.; Kleinman, H. K. (2005)
Thymosin beta-4, Actin sequestering protein moonlights to repair injured tissues.
Trends in Molecular Medicine, 11, 421-29
Huff, T.;Rosorius, O.;Otto, A. M.; Müller, C. S.; Ballweber, E.; Hannappel, E.; Mannherz, H. G. (2004)
Nuclear localisation of the G-actin sequestering peptide thymosin beta-4
J. Cell Sci., 117, 5333-5341
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Leeanansaksiri, W.; DeSimone, S.; Huff, T.; Hannappel, E.; Huff, T. F. (2004)
Thymosin beta-4 and its N-terminal tetrapeptide (acSDKP) induce mast cell degranulation and dysplastic non-apoptotic nuclei in cultured mast cells
Chemistry & Biodiversity, 1, 1091-100
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Philp, D.; Huff, T.; Gho, Y. S.; Hannappel, E.; Kleinman, H. (2003)
The actin binding site on thymosin beta-4 promotes angiogenesis
FASEB J., 17, 2103-5
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Müller, C. S. G.; Huff, T.; Hannappel, E. (2003)
Reduction of thymosin beta-4 and actin in HL60 cells during apoptosis is preceded by a decrease of their mRNAs
Mol Cell Biochem, 250, 179-188
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Otto, A. M.; Müller, C. S. G.; Huff, T.; Hannappel, E. (2002)
Chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells
J Cancer Res Clin Oncol, 128, 247-256
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Ballweber, E.; Hannappel, E.; Huff, T.; Stephan, H.; Haener, M.; Taschner, N.; Stoffler, D.; Aebi, U.; Mannherz, H. G. (2002)
Polymerization of chemically cross-linked actin - thymosin beta 4 complex to filamentous actin, Alteration in helical parameters and visualization of thymosin beta 4 binding to F- actin.
J. Mol. Biol., 315, 613-625
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Huff, T.; Otto, A. M.; Müller, C. S. G.; Meier, M.; Hannappel, E. (2002)
Thymosin beta 4 is released from human blood platelets and attached by factor XIIIa (transglutaminase) to fibrin and collagen.
FASEB J., 16, 691-696
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Huff, T.; Ballweber, E.; Humeny, A.; Bonk, T.; Becker, C. M.; Müller, C. S. G.; Mannherz, H. G.; Hannappel, E. (1999)
Thymosin beta 4 serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescent dansylcadaverine does not abolish interaction with G-actin.
FEBS Lett., 464, 14-20
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Huff, T.; Cappelletti, G.; Hannappel, E. (1998)
The dipyridyls paraquat and diquat attenuate the interaction of G-actin with thymosin beta 4.
FEBS Lett., 425, 495-498
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Ballweber, E.; Giehl, K.; Hannappel, E.; Huff, T.; Jockusch, B. M.; Mannherz, H. G. (1998)
Plant profilin induces actin polymerization from actin-beta-thymosin complexes and competes directly with beta-thymosins and with negative cooperativity with DNase I for binding to actin.
FEBS Lett., 425, 251-255
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Huff, T.; Mller, C.; Hannappel, E. (1997)
HPLC and post-column derivatization with fluorescamine, isolation of actin-sequestering beta-thymosins by reverse-phase HPLC.
Anal. Chim. Acta, 352, 239-248
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Ballweber, E.; Hannappel, E.; Huff, T.; Mannherz, H. G. (1997)
Mapping the binding site of thymosin beta 4 on actin by competing with G-actin binding proteins indicates negative co-operativity between binding sites located on opposite subdomains of actin.
Biochem. J., 327, 787-793
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Huff, T.; Hannappel, E. (1997)
Oxidation and reduction of thymosin beta 4 and its influence on the interaction with G- actin studied by reverse-phase HPLC and post-column derivatization with fluorescamine.
Anal. Chim. Acta, 352, 249-256
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Huff, T.; Müller, C. S .G.; Hannappel, E. (1997)
C-Terminal truncation of thymosin beta 10 by an intracellular protease and its influence on the interaction with G-actin studied by ultrafiltration.
FEBS Lett., 414, 39-44
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Huff, T.; Zerzawy, D.; Hannappel, E. (1995)
Interactions of beta-thymosins, thymosin beta 4-sulfoxide, and N-terminally truncated thymosin beta 4 with actin studied by equilibrium centrifugation, chemical crosslinking and viscometry.
Eur. J. Biochem., 230, 650-657,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7607239&dopt=Abstract
Ballweber, E.; Hannappel, E.; Niggemeyer, B.; Mannherz, H. G. (1994)
Induction of the polymerization of actin from the actin - thymosin beta 4 complex by phalloidin, skeletal myosin subfragment 1, chicken intestinal myosin I and free ends of filamentous actin.
Eur. J. Biochem., 223, 419-426,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7812086&dopt=Abstract
Hannappel, E.; Wartenberg, F. (1993)
Actin sequestering ability of thymosin beta 4, thymosin beta 4 fragments, and thymosin beta 4-like peptides as assessed by the DNase I inhibition assay.
Biol. Chem. Hoppe-Seyler, 374, 117-122,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8471179&dopt=Abstract
Schöbitz, B.; Hannappel, E.; Brand, K. (1991)
The early induction of the actin-sequestering peptide thymosin beta-4 in thymocytes depends on the proliferative stimulus.
Biochim. Biophys. Acta, 1095, 230-235,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1958698&dopt=Abstract
Schöbitz, B.; Netzker, R.; Hannappel, E.; Brand, K. (1991)
Cell-cycle-regulated expression of thymosin beta-4 in thymocytes.
Eur. J. Biochem., 199, 257-262,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1712726&dopt=Abstract
Grillon, C.; Rieger, K.; Bakala, J.; Schott, D.; Morgat, J. L.; Hannappel, E.; Voelter, W.; Lenfant, M. (1990)
Involvement of thymosin beta-4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSDKP a regulator of the hematopoietic system.
FEBS Lett., 274, 30-34,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2253778&dopt=Abstract
Mihelic, M.; Giebel, W.; Wei, N. R.; Hannappel, E.; Kalbacher, H.; Voelter, W. (1990)
Immunohistochemical localization of thymosin beta-9 in bovine tissues.
Histochem., 95, 175-178,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2081691&dopt=Abstract
Schöbitz, B.; Netzker, R.; Hannappel, E.; Brand, K. (1990)
Rapid induction of thymosin beta-4 in concanavalin A-stimulated thymocytes by translational control.
J. Biol. Chem., 265, 15387-15391,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2394730&dopt=Abstract
Zarbock, J.; Oschkinat, H.; Hannappel, E.; Kalbacher, H.; Voelter, W.; Holak, T. A. (1990)
Solution conformation of thymosin beta-4 - a nuclear magnetic resonance and simulated annealing study.
Biochemistry, 29, 7814-7821,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2261438&dopt=Abstract
Hannappel, E.; Wartenberg, F.; Bustelo, X. R. (1989)
Isolation and characterization of thymosin beta-9-Met from pork spleen.
Arch. Biochem. Biophys., 273, 396-402,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2774558&dopt=Abstract
Haritos, A. A.; Yialouris, P. P.; Heimer, E. P.; Felix, A. M.; Hannappel, E.; Rosemeyer, M. A. (1989)
Evidence for the monomeric nature of thymosins.
FEBS Lett., 244, 287-290,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2920828&dopt=Abstract
Mihelic, M.; Kalbacher, H.; Hannappel, E.; Voelter, W. (1989)
MicroELISA method for the determination of thyosin beta-9 discriminating between thymosin beta-9 and the structurally closely related thymosin beta-4.
J. Immunol. Methods, 122, 7-13,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2760477&dopt=Abstract
Hannappel, E.; Kalbacher, H.; Voelter, W. (1988)
Thymosin beta-4Xen - a new thymosin beta-4-like peptide in oocytes of Xenopus laevis.
Arch. Biochem. Biophys., 260, 546-551,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3124756&dopt=Abstract
Tsitsiloni, O. E.; Yialouris, P. P.; Heimer, E. P.; Felix, A. M.; Evangelatos, G. P.; Soteriadis Vlahos, C.; Stiakakis, J.; Hannappel, E.; Haritos, A. A. (1988)
A radioimmunoassay for parathymosin alpha using antibodies to synthetic N-terminal peptide 1-30.
J. Immunol. Methods, 113, 175-184,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3049827&dopt=Abstract
Hannappel, E.; van Kampen, M. (1987)
Determination of thymosin beta-4 in human blood cells and serum.
J. Chromatogr., 397, 279-285,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3654821&dopt=Abstract
Hannappel, E. (1986)
One-step procedure for the determination of thymosin beta-4 in small tissue samples and its separation from other thymosin beta-4 -like peptides by high-pressure liquid chromatography.
Anal. Biochem., 156, 390-396,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3766940&dopt=Abstract
Hannappel, E.; Leibold, W. (1985)
Biosynthesis rates and content of thymosin beta-4 in cell lines.
Arch. Biochem. Biophys., 240, 236-241,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2990345&dopt=Abstract
Horecker, B. L.; Erickson-Viitanen, S.; Hannappel, E. (1985)
Thymosin beta-4 like peptides.
Meth. Enzymol., 116, 265-269,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4088088&dopt=Abstract
Hannappel, E.; Davoust, S.; Horecker, B. L. (1982)
Isolation of peptides from calf thymus.
Biochem. Biophys. Res. Commun., 104, 266-271
Hannappel, E.; Davoust, S.; Horecker, B. L. (1982)
Thymosin beta-8 and beta-9, two new peptides isolated from calf thymus homologous to thymosin beta-4.
Proc. Natl. Acad. Sci. USA, 79, 1708-1711
Hannappel, E.; Xu, G. J.; Morgan, J.; Hempstead, J.; Horecker, B. L. (1982)
Thymosin beta-4 - a ubiquitous peptide in rat and mouse tissues.
Proc. Natl. Acad. Sci. USA, 79, 2172-2175
Xu, G. J.; Hannappel, E.; Morgan, J.; Hempstead, J.; Horecker, B. L. (1982)
Synthesis of thymosin beta-4 by peritoneal macrophages and adherent spleen cells.
Proc. Natl. Acad. Sci. USA, 79, 4006-4009
Freire, M.; Hannappel, E.; Rey, M.; Freire, J. M.; Kido, H.; Horecker, B. L. (1981)
Purification of thymus mRNA coding for a 16000 dalton polypeptide containing the thymosin alpha-1 sequence.
Proc. Natl. Acad. Sci. USA, 78, 192-195
Kido, H.; Vita, A.; Hannappel, E.; Horecker, B. L. (1981)
Aminoterminal acetylation of synthetic N-alpha-desacetyl thymosin alpha-1.
Arch. Biochem. Biophys., 208, 95-100

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II. Lung-Surfactant

Gommers, D.; Vilstrup, C.; Bos, J. A.; Larsson, A.; Werner, O.; Hannappel, E.; Lachmann, B. (1993)
Exogenous surfactant therapy increases static lung compliance, and cannot be assessed by measurements of dynamic compliance alone.
Crit. Care Med., 21, 567-574,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8472578&dopt=Abstract
Bos, J. A.; Wollmer, P.; Bakker, W.; Hannappel, E.; Lachmann, B. (1992)
Clearance of 99mTc-DTPA and experimentally increased alveolar surfactant content.
J. Appl. Physiol., 72, 1413-1417,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1592733&dopt=Abstract
Eijking, E. P.; van-Daal, G. J.; Tenbrinck, R.; Sluiters, J. F.; Hannappel, E.; Erdmann, W.; Lachmann, B. (1992)
Improvement of pulmonary gas exchange after surfactant replacement in rats with Pneumocystis carinii pneumonia.
Adv. Exp. Med. Biol., 316, 293-298,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1288089&dopt=Abstract
Van-Daal, G. J.; Bos, J. A.; Eijking, E. P.; Gommers, D.; Hannappel, E.; Lachmann, B. (1992)
Surfactant replacement therapy improves pulmonary mechanics in end-stage influenza A pneumonia in mice.
Am. Rev. Resp. Dis., 145, 859-863,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1313214&dopt=Abstract
Voss, T.; Schäfer, K. P.; Nielsen, P. F.; Schäfer, A.; Maier, C.; Hannappel, E.; Maassen, J.; Landis, B.; Klemm, K.; Przybylski, M. (1992)
Primary structure differences of human surfactant-associated proteins isolated from normal and proteinosis lung.
Biochim. Biophys. Acta, 1138, 261-267,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1562613&dopt=Abstract
Eijking, E. P.; Strayer, D. S.; van-Daal, G. J.; Tenbrinck, R.; Merritt, T. A.; Hannappel, E.; Lachmann, B. (1991)
In vivo and in vitro inactivation of bovine surfactant by an anti-surfactant monoclonal antibody.
Eur. Resp. J., 4, 1245-1250,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1804672&dopt=Abstract
Eijking, E. P.; van-Daal, G. J.; Tenbrinck, R.; Luijendijk, A.; Sluiters, J. F.; Hannappel, E.; Lachmann, B. (1991)
Effect of surfactant replacement on Pneumocystis carinii pneumonia in rats.
Intensive Care Med., 17, 475-478,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1797892&dopt=Abstract

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III. Enzymology

Hannappel, E.; Fischer, W.; Brand, K. (1987)
Laboratory experiments on the regulation of pyruvate kinase isoenzymes.
Biochem. Education, 15, 42-43
Hannappel, E.; MacGregor, J. S.; Davoust, S.; Horecker, B. L. (1982)
Limited proteolysis of liver and muscle aldolases - effects of subtilisin, cathepsin B and Staphylococcus aureus protease.
Arch. Biochem. Biophys., 214, 293-298
MacGregor, J. S.; Hannappel, E.; Xu, G. J.; Pontremoli, S.; Horecker, B. L. (1982)
Conservation of primary structure at the proteinase-sensitive site of fructose 1,6- bisphosphatase.
Arch. Biochem. Biophys., 217, 652-664,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6291465&dopt=Abstract
Sun, S. C.; Datta, A. G.; Hannappel, E.; Singh, V. N.; Tsolas, O.; Melloni, B.; Pontremoli, S.; Horecker, B. L. (1981)
The carboxy-terminal amino acid sequence of rabbit liver fructose 1,6-bisphosphatase.
Arch. Biochem. Biophys., 206, 265-270
Weigand, W.; Hannappel, E.; Brand, K. (1980)
Effect of starvation and refeeding a high-protein or high-carbohydrate diet on lipid composition and glycogen content of rat livers in relation to age.
J. Nutr., 110, 669-674

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IV. Other

R. Atreya, H. Neumann, C. Neufert, M. J. Waldner, U. Billmeier, Y. Zopf, M. Willma, C. App, T. Münster, H. Kessler, S. Maas, B. Gebhardt, R. Heimke-Brinck, E. Reuter, F. Dörje, T. T. Rau, W. Uter, T. D. Wang, R. Kiesslich, M. Vieth, E. Hannappel & M. F. Neurath (2014)
In vivo molecular imaging using fluorescent anti-TNF antibodies and confocal
laser endomicroscopy predicts response to biological therapy in Crohn’s
Nat Med, 20(3), 313-318
Villmann, C.; Sandmeier, B.; Seeber, S.; Hannappel, E.; Pischetsrieder, M.; Becker, C.M. (2007)
Myelin proteolipid protein (PLP) as a marker antigen of central nervous system contaminations for routine food control
J Agric Food Chem, 55, 7114-23
Stuible, H. P.; Meier, S.; Wagner, C.; Hannappel, E.; Schweizer, E. (1998)
A novel phosphopanthetheine,protein transferase activating yeast mitochondrial acyl carrier protein.
J. Biol. Chem., 273, 2234-2239,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9712852&dopt=Abstract
Armesto, J.; Hannappel, E.; Leopold, K.; Fischer, W.; Bublitz, R.; Langer, L.; Cumme, G. A.; Horn. A. (1996)
Microheterogeneity of the hydrophobic and hydrophilic part of the glycosylphosphatidylinositol anchor of alkaline phosphatase from calf intestine.
Eur. J. Biochem., 238, 259-269,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8665945&dopt=Abstract
Behr, T.; Becker, W.; Hannappel, E.; Goldenberg, D. M.; Wolf, F. (1995)
Targeting of liver metastases of colorectal cancer with IgG, F(abNULL)2, and FabNULL anti- carcinoembryonic antigen antibodies labeled with 99mTc, the role of metabolism and kinetics.
Cancer Res., 55, 5777s-5785s,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7493346&dopt=Abstract
Küchle, M.; Nguyen, N. X.; Hannappel, E.; Naumann, G. O. H. (1995)
The blood-aqueous barrier in eyes with pseudoexfoliation syndrome.
Ophthalmic Res., 27, 136-142,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8577452&dopt=Abstract
Behr, T.; Becker, W.; Hannappel, E.; Wolf, F. (1994)
Structural modifications of monoclonal antibodies following direct versus indirect labelling with 99Tcm, does fragmentation really occur?
Nucl. Med. Commun., 15, 865-870,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7870392&dopt=Abstract
Küchle, M.; Ho, T. S.; Nguyen, N. X.; Hannappel, E.; Naumann, G. O. H. (1994)
Protein quantification and SDS-PAGE electrophoresis in aqueous humor of pseudoexfoliation eyes.
Invest. Ophthalmol. Visual Sci., 35, 748-752,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8113026&dopt=Abstract
Küchle, M.; Nguyen, N. X.; Hannappel, E.; Beck, W.; Ho, S. T.; Naumann, G. O. H. (1994)
Measurement of aqueous flare and determination of aqueous protein concentration in eyes with pseudoexfoliation syndrome.
Ophthalmologe, 91, 578-584,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7812086&dopt=Abstract
Bublitz, R.; Armesto, J.; Hoffmann-Blume, E.; Schulze, M.; Rhode, H.; Horn, A.; Aulwurm, S.; Hannappel, E.; Fischer, W. (1993)
Heterogeneity of glycosylphosphatidylinositol anchored alkaline phosphatase of calf intestine.
Eur. J. Biochem., 217, 199-207,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8223555&dopt=Abstract
Küchle, M.; Hannappel, E.; Nguyen, N. X.; Ho, S. T.; Beck, W.; Naumann, G. O. H. (1993)
Correlation between tyndallometry with the laser flare cell meter in vivo and biochemical protein determination in human aqueous humor [Korrelation zwischen Tyndallometrie mit dem Lase Flare-Cell Meter in vivo und biochemischer Proteinbestimmung im menschlichen Kammerwasser].
Klin. Mbl. Augenheilk., 202, 14-18,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8464199&dopt=Abstract
Hannappel, E.; Pankow, G.; Grassl, F.; Brand, K.; Naumann, G. O. H. (1985)
Amino acid pattern in human aqueous humor of patients with senile cataract and primary open-angle glaucoma.
Ophthal. Res., 17, 341-343,80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4069571&dopt=Abstract

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