der Medizinischen Fakultät im Emil-Fischer-Centrum

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AG Xiang

Leitung: Dr. Wei Xiang


Schreglmann SR, Regensburger M, Rockenstein E, Masliah E, Xiang W, Winkler J, Winner B (2015)
The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice.
PLoS One, 11; 10(5):e0126261
Xiang W, Menges S, Schlachetzki JCM, Meixner H, Hoffmann A-C, Schlötzer-Schrehardt U, Becker CM, Winkler J, Klucken J (2015)
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.
Molecular Neurodegeneration, 10: 8
Eckstein M, Zimmermann R, Roth T, Hauck-Dlimi B, Strasser EF, Xiang W (2015)
The effects of an overnight holding of whole blood at room temperature on hemoglobin modification and in vitro markers of red blood cell aging.
Vox Sang, 108(4): 359-67
Eckstein FM, Xiang W, Kretzschmar HA, Sun QL, Gao C, Xu Y, Wang H, Fan XY, Meng G, Li W, Dong XP (2014)
The influence of pre-analytical conditions on platelet-derived microparticles.
Clin Lab., 60: 707-16
Eckstein FM, Xiang W, Weiss DR, Zimmermann R, Strasser EF (2014)
The influence of pre-analytical conditions on platelet-derived microparticles.
Clin Lab. , 60:707-16.
Tian C, Liu D, Xiang W, Kretzschmar HA, Sun QL, Gao C, Xu Y, Wang H, Fan XY, Meng G, Li W, Dong XP (2014)
Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI) and Alzheimer’s disease (AD).
Mol Neurobiol, 50 (2): 473-481
Poehler AM, Xiang W, Spitzer P, May VEL, Meixner H, Rockenstein E, Marques O, Outeiro TF, Winkler J, Eliezer E, Klucken J (2014)
Autophagy modulates alpha-synuclein release and microenvironmental response.
Autophagy, 10 (12): 2171-2192
Ettle B, Reiprich S, Deusser J, Schlachetzki JCM, Xiang W, Prots I, Winner B, Wegner M, Winkler J (2014)
Link between intracellular alpha-synuclein level and maturation potential of primary oligodendrocyte progenitor cells.
Mol Cell Neurosci, 62: 68-78
Xiang W, Weisbach V, Sticht H, Seebahn A, Bussmann J, Zimmermann R, Becker CM (2013)
Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes.
Arch Biochem Biophys, 529:34-44
Xiang W, Schlachestzki JCM, Helling S, Bussmann JC, Berlinghof M, Schäffer TM, Marcus K, Winkler J, Klucken J, Becker CM (2013)
Oxidative stress-induced posttranlational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity.
Mol and Cell Neurosci, 54:71-83
Tian C, Liu D, Sun QL, Chen C, Xu Y, Wang H, Xiang W, Kretzschmar HA, Li W, Chen C, Shi Q, Gao C, Zhang J, Zhang BY, Han J, Dong XP (2013)
Comparative analysis of gene expression profiles between cortex and thalamus in chinese fatal familial insomnia patients.
Mol Neurobiol, 48:36-48
Miranda HV, Xiang W, de Oliveira RM, Simões T, Pimentel J, Klucken J, Penque D, Outeiro TF (2013)
Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post translational modifications.
J Neurochem, 126:673-84
Guo D, Xiang W, Seebahn A, Becker CM, Strauss O (2012)
Modulation of TTX-sensitive voltage-dependent Na+ channels by beta-bungarotoxin in rat cerebellar neurons.
BMC Neurosci, 13:36
Tang Y, Xiang W, Terry L, Kretzschmar HA, Windl O (2010)
Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy.
PLoS One, 5(12):e14207
Tang Y, Xiang W, Hawkins SA, Kretzschmar HA, Windl O (2009)
Transcriptional changes in the brain of cattle orally infected with BSE precede detection of infectivity.
J Virol, 83(18):9464-73
Wagner I, Sethi S, Xiang W, Giese A, Ebner S, Kretzschmar H (2008)
Repeated peripheral administrations of CpG oligodeoxynucleotides lead to sustained CNS immune activation.
Immunopharmacol Immunotoxicol, 29(3-4):413-24
Roeber S, Grasbon-Frodl EM, Windl O, Krebs B, Xiang W, Vollmert C, Illig T,Schröter A, Arzberger T, Weber P, Zerr I, Kretzschmar HA (2008)
Evidence for a pathogenic role of different mutations at codon 188 of PRNP.
PLoS ONE, 3(5):e2147
Schmalzbauer R, Eigenbrod S, Winoto-Morbach S, Xiang W, Schütze S, Bertsch U, Kretzschmar HA (2008)
Evidence for an association of prion protein and sphingolipid-mediated signaling.
J Neurochem, 106(3):1459-1470
Mitteregger G, Vosko M, Krebs B, Xiang W, Kohlmannsperger V, Nölting S, Hamann GF, Kretzschmar HA (2007)
The role of the octarepeat region in neuroprotective function of the cellular prion protein.
Brain Pathol, 17(2):174-83
Xiang W, Hummel M, Mitteregger G, Pace C, Windl O, Mansmann U, Kretzschmar HA (2007)
Transcriptome analysis reveals altered cholesterol metabolism during the neurodegeneration in mouse scrapie model.
J Neurochem, 102(3):834-47
Vollmert C, Windl O, Xiang W, Rosenberger A, Zerr I, Wichmann HE, Bickeboller H, Illig T; KORA group; Kretzschmar HA (2006)
Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study.
J Med Genet, 43(10):e53
Xiang W, Windl O, Westner IM, Neumann M, Zerr I, Lederer RM, Kretzschmar HA (2005)
Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease.
AnnNeurol, 58(2):242-57
Riemenschneider M, Klopp N, Xiang W, Wagenpfeil S, Vollmert C, Muller U, Forstl H, Illig T, Kretzschmar H, Kurz A (2004)
Prion protein codon 129 polymorphism and risk of Alzheimer disease.
Neurology, 63(2):364-6
Xiang W, Windl O, Wunsch G, Dugas M, Kohlmann A, Dierkes N, Westner IM, Kretzschmar HA (2004)
Identification of differentially expressed genes in scrapie-infected mouse brains by using global gene expression technology.
J Virol, 78(20):11051-60
Wimberger P, Xiang W, Mayr D, Diebold J, Dreier T, Baeuerle PA, Kimmig R (2003)
Efficient tumor cell lysis by autologous, tumor-resident T lymphocytes in primary ovarian cancer samples by an EP-CAM-/CD3-bispecific antibody.
Int J Cancer, 105(2):241-8
Xiang W, Wimberger P, Dreier T, Diebold J, Mayr D, Baeuerle PA, Kimmig R (2003)
Cytotoxic activity of novel human monoclonal antibody MT201 against primary ovarian tumor cells.
J Cancer Res Clin Oncol, 129(6):341-8
Weingandt H, Stepp H, Baumgartner R, Diebold J, Xiang W, Hillemanns P (2002)
Autofluorescence spectroscopy for the diagnosis of cervical intraepithelial neoplasia.
BJOG, 109(8):947-51
Betz CS, Lai JP, Xiang W, Janda P, Heinrich P, Stepp H, Baumgartner R, Leunig A (2002)
In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid.
Photochem Photobiol Sci, 1(5):315-9
Xiang W, Weingandt H, Liessmann F, Klein S, Stepp H, Baumgartner R, Hillemanns P (2001)
Photodynamic effects induced by aminolevulinic acid esters on human cervical carcinoma cells in culture.
Photochem Photobiol, 74(4):617-23
Hillemanns P, Weingandt H, Baumgartner R, Diebold J, Xiang W, Stepp H (2000)
Photodetection of cervical intraepithelial neoplasia using 5-aminolevulinic acid-induced porphyrin fluorescence.
Cancer , 88(10):2275-82
Hillemanns P, Weingandt H, Stepp H, Baumgartner R, Xiang W, Korell M (2000)
Assessment of 5-aminolevulinic acid-induced porphyrin fluorescence in patients with peritoneal endometriosis
Am J Obstet Gynecol, 183(1):52-7
Xiang W, Rensing L (1999)
Changes in cell morphology and actin organization during heat shock in Dictyostelium discoideum: does HSP70 play a role in acquired thermotolerance?
FEMS Microbiol Lett, 178(1):95-107
Killich T, Plath PJ, Hass EC, Xiang W, Bultmann H, Rensing L, Vicker MG (1994)
Cell movement and shape are non-random and determined by intracellular, oscillatory rotating waves in Dictyostelium amoebae.
Biosystems, 33(2):75-87
Killich T, Plath PJ, Xiang W, Bultmann H, Rensing L, Vicker MG (1993)
The locomotion, shape and pseudopodial dynamics of unstimulated Dictyostelium cells are not random.
J Cell Sci, ( Pt 4):1005-13

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