der Medizinischen Fakultät im Emil-Fischer-Centrum

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Professur für Molekulare Medizin mit dem Schwerpunkt Molekulare Bildgebung

Leitung: Prof. Dr. Dieter Chichung Lie

Reviews

Beckervordersandforth R, Zhang CL, Lie DC. (2015)
Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis.
Cold Spring Harb Perspect Biol., Oct 1;7(10):a018879
Schwarz T, Ebert B, Lie DC (2012)
Stem Cell Maintenance in the Adult Mammalian Hippocampus: a Matter of Signal Integration?
Dev. Neurobiology, 72(7):1006-15
Merz K, Herold S, Lie DC (2011)
CREB in adult neurogenesis--master and partner in the development of adult-born neurons?
Eur J Neurosci,, 33:1078-1086
Khan MA, Lie DC (2011)
MicroRNA - a contributor to age-associated neural stem cell dysfunction?
Aging (Albany NY) , 3:182-183.
Covic M, Karaca E, Lie DC. (2010)
Epigenetic regulation of neurogenesis in the adult Hippocampus.
Heredity, Mar 24. [Epub ahead of print]
Winner B, Vogt-Weisenhorn DM, Lie DC, Blümcke I, Winkler J. (2009)
Cellular Repair Strategies in Parkinson’s disease.
Therap Adv Neurol Disord, 2(1): 51-60.
Khan MA, Berti L. (2009)
Alzheimer's disease affects progenitor cells through aberrant {beta}-catenin signaling.
J Neurosci. , 29(40): 12369-12371.
Michaelidis TM, Lie DC. (2008)
Wnt signaling and neural stem cells: caught in the Wnt web.
Cell Tissue Res , 331(1):193-210
Jagasia R, Song H, Gage FH, Lie DC. (2006)
New regulators in adult neurogenesis and their potential role for repair.
Trends Mol Med , 12:400-40
Lie DC, Song HJ, Colamarino SA, Ming GL, Gage FH. (2004)
Neurogenesis in the adult brain; new strategies for central nervous system diseases.
Annu Rev Pharmacol Toxicol, 44: 399-421
Song HJ, Lie DC, Stevens CF, Gage FH. (2003)
Reply: Familial dementia with dentate atrophy and failure of neurogenesis.
Ann Neurol , 53 (3):421

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Publications

Gebara E, Bonaguidi MA, Beckervordersandforth R, Sultan S, Udry F, Gijs PJ, Lie DC, Ming GL, Song H, Toni N. (2016)
Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus.
Stem Cells, Jan 4. doi: 10.1002
Marschallinger J, Schäffner I, Klein B, Gelfert R, Rivera FJ, Illes S, Grassner L, Janssen M, Rotheneichner P, Schmuckermair C, Coras R, Boccazzi M, Chishty M, Lagler FB, Renic M, Bauer HC, Singewald N, Blümcke I, Bogdahn U, Couillard-Despres S, Lie DC, Abbracchio MP, Aigner L. (2015)
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.
Nat Commun., Oct 27;6:8466
Cernilogar FM, Di Giaimo R, Rehfeld F, Cappello S, Lie DC. (2015)
RNA interference machinery-mediated gene regulation in mouse adult neural stem cells.
BMC Neurosci., Sep 19;16:60
Andreu Z, Khan MA, González-Gómez P, Negueruela S, Hortigüela R, San Emeterio J, Ferrón SR, Martínez G, Vidal A, Fariñas I, Lie DC, Mira H. (2015)
The cyclin-dependent kinase inhibitor p27 kip1 regulates radial stem cell quiescence and neurogenesis in the adult hippocampus.
Stem Cells, Jan;33(1):219-29
Steib K, Schäffner I, Jagasia R, Ebert B, Lie DC. (2014)
Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain.
J Neurosci., May 7;34(19):6624-33
Beckervordersandforth R, Deshpande A, Schäffner I, Huttner HB, Lepier A, Lie DC, Götz M. (2014)
In Vivo Targeting of Adult Neural Stem Cells in the Dentate Gyrus by a Split-Cre Approach.
Stem Cell Reports, Feb 6;2(2):153-62
Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M. (2014)
The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network.
Cell Stem Cell, Oct 3;13(4):403-18
Sun M, Hölter SM, Stepan J, Garrett L, Genius J, Kremmer E, Hrabe de Angelis M, Wurst W, Lie DC, Bally-Cuif L, Eder M, Rujescu D, Graw J. (2013)
Crybb2 coding for ßB2-crystallin affects sensorimotor gating and hippocampal function.
Mamm Genome, Oct;24(9-10):333-48
Ortega F, Gascón S, Masserdotti G, Deshpande A, Simon C, Fischer J, Dimou L, Chichung Lie D, Schroeder T, Berninger B. (2013)
Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling.
Nat Cell Biol., Jun;15(6):602-13
Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Lie DC, Jossin Y, Vanderhaeghen P. (2013)
Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration.
Neuron, Sep 18;79(6):1123-35
Merz K, Lie DC. (2013)
Evidence that Doublecortin is dispensable for the development of adult born neurons in mice.
PLoS One., 8(5):e62693.
Ortega F, Gascón S, Masserdotti G, Deshpande A, Simon C, Fischer J, Dimou L, Chichung Lie D, Schroeder T, Berninger B. (2013)
Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling.
Nat Cell Biol., 15(6):602-13. doi: 10.1038/ncb2736. Epub 2013 May 5.
Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M. (2013)
The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network.
Cell Stem Cell, pii: S1934-5909(13)00310-X. doi: 10.1016/j.stem.2013.07.002. [Epub ahead of print]
Niv F, Keiner S, Krishna K, Witte OW, Lie DC, Redecker C. (2012)
Aberrant Neurogenesis After Stroke: A Retroviral Cell Labeling Study.
Stroke., 43(9):2468-75.
Karow M, Sánchez R, Schichor C, Masserdotti G, Ortega F, Heinrich C, Gascón S, Khan MA, Lie DC, Dellavalle A, Cossu G, Goldbrunner R, Götz M, Berninger B. (2012)
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells.
Cell Stem Cell, 11(4):471-6.
Herold S, Jagasia R, Merz K, Wassmer K, Lie DC (2011)
CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventrivular zone neurogenesis.
Mol Cell Neurosci, 46:79-88.
Karalay O, Doberauer K, Vadodaria KC, Knobloch M, Berti L, Miquelajauregui A, Schwark M, Jagasia R, Taketo MM, Tarabykin V, Lie DC, Jessberger S (2011)
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis.
Proc Natl Acad Sci U S A, 108:5807-5812.
Rolyan H, Scheffold A, Begus-Nahrmann Y, Heinrich A, Liss B, Langkopf BH, Hölter SM, Vogt Weissenhorn DM, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. (2011)
Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice.
Brain, 134(Pt 7):2044-56.
Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I and Gage FH. (2010)
Signalling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.
Cell Stem Cell, 7(1):78-89
Ehm O, Göritz C, Covic M, Karaca E, Schaeffner I, Schwarz T, Kempkes B, Kremmer E, Pfrieger FW, Espinosa L, Bigas A, Giachino C, Taylor V, Frisén J, Lie DC (2010)
RBPJ-dependent signalling regulates Sox2 expression and is essential for longterm maintenance of radial glia like stem cells in the adult hippocampus.
J Neurosci. , 30:13794-13807.
Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, Gotz M (2010)
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.
Cell Stem Cell, 7:744-758.
Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr, Consiglio A, Lie DC, Squire LR, Gage FH. (2009)
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats.
Learn Mem., 16(2):147-54
Kuwabara T, Muotri A, Warashin M, Lie DC, Nakashima K, Hsieh J, Moore L, Asashima M and Gage FH. (2009)
Wnt-mediated activation of NeuroD1 and retroelements during adult neurogenesis.
Nat Neurosci., 12(9):1097-105. Epub 2009 Aug 23.
Haslinger A, Schwarz TJ, Covic M, Lie DC. (2009)
Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis.
Eur J Neurosci., 29(11):2103-14
Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage FH, Song H, Lie DC. (2009)
GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus.
J Neurosci. , 29(25):7966-77
Jessberger S, Aigner S, Clemenson GD Jr, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage FH. (2008)
Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus.
PLoS Biol., 6(11):e272.
Winner B, Rockenstein E, Lie DC, Aigner R, Mante M, Bogdahn U, Couillard-Depres S, Masliah E, Winkler J. (2007)
Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.
Neurobiol Aging, 29(6):913-25. Epub 2007 Jan 31
Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM. (2006)
Retinoic acid is required early during adult neurogenesis in the dentate gyrus.
Proc Natl Acad Sci U S A, 103:3902-3907.
Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH. (2005)
Wnt signalling regulates adult hippocampal neurogenesis.
Nature, 437(7063):1370-5.
Wurmser AE, Summers RG, Nakashima K, Toni N, D’Amour KA, Lie DC, Gage FH. (2004)
Cell fusion-independent differentiation of neural stem cells to the endothelial lineage.
Nature, 430: 350-356
Shi YH, Lie DC, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. (2004)
Expression and function of orphan nuclear receptor TLX in adult neural stem cells.
Nature, 427: 78-83
Winner B, Lie DC, Rockenstein E, Aigner R, Masliah E, Kuhn HG, Winkler J. (2004)
Impairment of adult neurogenesis in transgenic human alpha-synuclein mice.
J Neuropathol Exp Neurol, 63(11):1155-66
Dziewczapolski G, Lie DC, Ray J, Gage FH, Shults CW. (2003)
Survival and differentiation of adult rat-derived neural progenitor cells transplanted to the striatum of hemiparkinsonian rats.
Exp Neurol, 183: 653-664
Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage FH. (2002)
The adult substantia nigra contains progenitor cells with neurogenic potential.
J Neurosci., 22(15):6639-49.
Matsuura N*, Lie DC*, Hoshimaru M, Asahi M, Hojo M, Ishizaki R, Hashimoto N, Noji S, Ohuchi H, Yoshioka H, Gage FH. (2001)
Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line.
(*equal contribution)
J Neurosci , 21:4326-4335.
Weis J, Schonrock LM, Zuchner SL, Lie DC, Sure U, Schul C, Stogbauer F, Ringelstein EB, Halfter H. (1999)
CNTF and its receptor subunits in human gliomas.
J Neurooncol , 44:243-253
Weis J, Lie DC, Ragoss U, Zuchner SL, Schroder JM, Karpati G, Farruggella T, Stahl N, Yancopoulos GD, DiStefano PS. (1998)
Increased expression of CNTF receptor alpha in denervated human skeletal muscle.
J Neuropathol Exp Neurol , 57:850-857
Lie DC, Weis J. (1998)
GDNF expression is increased in denervated human skeletal muscle.
Neurosci Lett. , 250(2):87-90.

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Book Chapters

Jagasia R, Lie DC. (2009)
Hippocampal Neurogenic Niche and Regulation of Adult Neurogenesis.
Buchkapitel in “Postnatal and Adult Neurogenesis”. , Research Signpost. L Bonfanti (ed)
Lie DC, Gotz M. (2008)
Proliferation, Fate Determination, and Migration.
Buchkapitel in “Adult neurogenesis”., Cold Spring Harbor Laboratory Press. FH Gage, G Kempermann, H Song (eds).
Zhao X, Lie DC, Gage FH. (2006)
Adult derived stem cells for transplantation in Parkinson’s disease.
Buchkapitel in “Restorative therapies in Parkinson’s disease”., Kluwer Academic/Plenum Publishers. W Olanow and P Brundin (eds)
Lie DC, Song H, Colamarino SA, Gage FH. (2004)
Harnessing endogenous stem cells for CNS repair.
Buchkapitel in “Neuroscience, Molecular Medicine and the Therapeutic Transformation of Neurology”. , Elsevier Press. SG Waxman (ed)

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